评估洗衣粉对特应性皮炎患者皮肤微生物群的影响——一项临床研究。
Evaluating the Impact of Laundry Detergents on the Skin Microbiome of Atopic Dermatitis Patients-A Clinical Study.
作者信息
Christou Demetrios, Stevanovic Katarina, Evers Stefan, Weide Mirko, Zuberbier Torsten
机构信息
Institute of Allergology Charité-Universitätsmedizin Berlin Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology Berlin Germany.
出版信息
Health Sci Rep. 2024 Dec 17;7(12):e70261. doi: 10.1002/hsr2.70261. eCollection 2024 Dec.
BACKGROUND AND AIMS
Remnants of laundry detergent ingredients are suspected to be in constant contact with the skin. Allergy sufferers need assurance that the chemicals in everyday products do not cause such disruption. The purpose of this study was to evaluate the effects and tolerability of common laundry detergents on the skin microbiome in individuals with atopic dermatitis.
METHODS
Two laundry detergents for sensitive skin were tested on subjects with atopic dermatitis by having to wear detergent-washed socks for 7 days. The bacterial population from volunteers' skin swabs was determined and bacterial viability and biodiversity was evaluated before and after wearing the detergent-washed socks. The tolerability and effect on atopic dermatitis was also evaluated.
RESULTS
The results showed that the tested laundry detergents did not have a negative effect on bacterial viability or biodiversity on the skin after being exposed to the detergent-washed socks for a week. The laundry detergents were rated as very good on the tolerability scale and no worsening of skin itch was reported with the use of either detergent.
CONCLUSION
The results of the study showed that both laundry detergents are skin and allergy friendly and do not alter the skin microbiome.
背景与目的
怀疑残留的洗衣粉成分会持续接触皮肤。过敏患者需要确保日常用品中的化学物质不会造成此类干扰。本研究的目的是评估普通洗衣粉对特应性皮炎患者皮肤微生物群的影响和耐受性。
方法
通过让患有特应性皮炎的受试者穿着用洗衣粉洗涤过的袜子7天，对两种敏感皮肤用洗衣粉进行测试。在穿着用洗衣粉洗涤过的袜子前后，测定志愿者皮肤拭子中的细菌数量，并评估细菌活力和生物多样性。还评估了对特应性皮炎的耐受性和影响。
结果
结果表明，经过一周接触用洗衣粉洗涤过的袜子后，测试的洗衣粉对皮肤细菌活力或生物多样性没有负面影响。洗衣粉在耐受性量表上被评为非常好，使用任何一种洗衣粉均未报告皮肤瘙痒加剧。
结论
研究结果表明，两种洗衣粉对皮肤和过敏都很友好，不会改变皮肤微生物群。
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