Liu Tingwu, Wang Zilin, Zhang Xu, Xu Donghua, Yan Qiuyan, Chen Yuanwei, Luan Shifang
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
University of Science and Technology of China, Anhui 230026, P. R. China.
Biomater Sci. 2025 Jan 28;13(3):688-696. doi: 10.1039/d4bm01494d.
Instant adhesion to wet biological surfaces and reduced swelling of tissue adhesives are crucial for rapid wound closure and hemostasis. However, previous strategies to reduce swelling were always accompanied by a decrease in the tissue bonding strength of the adhesive. Moreover, the irreducibility of the covalent bonds in currently reported adhesives results in the adhesives losing their tissue adhesive ability. To tackle the challenge, a superior anti-swelling coacervate adhesive possessing fast self-healing properties through physical interactions (electrostatic interactions, hydrogen bonding) and chemical crosslinking (Schiff base reaction) was obtained with aldehyde-modified γ-PGA (γ-PGA-CHO), a natural lysozyme (LZM) and an amyloid fiber reduced lysozyme (RLZM). The instant shear adhesion strength and burst pressure tolerance of the adhesive on wet pig intestine reached 50.8 kPa (2.6 times that of CA glue) and 142.5 mmHg (5.9 times that of CA glue), and it maintained an adhesion strength of 37.4 kPa after exposure to the physical environment for 12 h and the swelling rate was only 34.0% underwater. The and experiments provided the coacervate adhesive with potential applicability for emergency rescue and wound care scenarios.
对湿生物表面的即时粘附以及组织粘合剂肿胀的减少对于快速伤口闭合和止血至关重要。然而，先前减少肿胀的策略总是伴随着粘合剂组织结合强度的降低。此外，目前报道的粘合剂中，共价键的不可还原性导致粘合剂失去其组织粘附能力。为应对这一挑战，通过醛基修饰的γ-聚谷氨酸（γ-PGA-CHO）、天然溶菌酶（LZM）和淀粉样纤维还原溶菌酶（RLZM），获得了一种具有快速自愈特性的优异抗肿胀凝聚层粘合剂，其通过物理相互作用（静电相互作用、氢键）和化学交联（席夫碱反应）实现自愈。该粘合剂在湿猪肠上的即时剪切粘附强度和爆破压力耐受性分别达到50.8 kPa（是CA胶的2.6倍）和142.5 mmHg（是CA胶的5.9倍），在物理环境中暴露12小时后仍保持37.4 kPa的粘附强度，在水下的肿胀率仅为34.0%。 实验和 实验为凝聚层粘合剂在紧急救援和伤口护理场景中的潜在应用提供了依据。 （注：原文中“ and experiments”部分内容缺失，翻译时保留原文表述）
