Shen Kaixiang, Lv Zhuting, Yang Yuxuan, Wang Haoyue, Liu Jiancheng, Chen Qifei, Liu Zheng, Zhang Mengyuan, Liu Jiaying, Cheng Yilong
Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.
Adv Mater. 2025 Feb;37(6):e2414092. doi: 10.1002/adma.202414092. Epub 2024 Dec 23.
Hydrogel bioadhesives with adequate wet adhesion and swelling resistance are urgently needed in clinic. However, the presence of blood or body fluid usually weakens the interfacial bonding strength, and even leads to adhesion failure. Herein, profiting from the unique coupling structure of carboxylic and phenyl groups in one component (N-acryloyl phenylalanine) for interfacial drainage and matrix toughening as well as various electrostatic interactions mediated by zwitterions, a novel hydrogel adhesive (PAAS) is developed with superior tissue adhesion properties and matrix swelling resistance in challenging wet conditions (adhesion strength of 85 kPa, interfacial toughness of 450 J m, burst pressure of 514 mmHg, and swelling ratio of <4%). The PAAS hydrogel can not only realize fast hemostasis of liver, heart, artery rupture, and sealing of pulmonary air-leakage but also accelerate the recovery of stomach and liver defects in rat, rabbit, and pig models. Moreover, PAAS hydrogel can precisely and durably monitor various physiological activities (pulse, electrocardiogram, and electromyogram) even under humid environments (immersion in water for 3 days), and can be employed for the evaluation of in vivo sealing efficiency for artery rupture. The work provides a promising hydrogel adhesive for clinical hemostasis, tissue injury repair, and bioelectronics.
临床上迫切需要具有足够湿粘附力和抗膨胀性的水凝胶生物粘合剂。然而，血液或体液的存在通常会削弱界面结合强度，甚至导致粘附失败。在此，得益于一种组分（N-丙烯酰基苯丙氨酸）中羧基和苯基的独特耦合结构用于界面排水和基质增韧，以及两性离子介导的各种静电相互作用，开发了一种新型水凝胶粘合剂（PAAS），其在具有挑战性的潮湿条件下具有优异的组织粘附性能和基质抗膨胀性（粘附强度为85 kPa，界面韧性为450 J/m，爆破压力为514 mmHg，溶胀率<4%）。PAAS水凝胶不仅可以实现肝脏、心脏、动脉破裂的快速止血以及肺漏气的封堵，还可以加速大鼠、兔子和猪模型中胃和肝脏缺损的恢复。此外，PAAS水凝胶即使在潮湿环境（在水中浸泡3天）下也能精确且持久地监测各种生理活动（脉搏、心电图和肌电图），并可用于评估动脉破裂的体内封堵效率。这项工作为临床止血、组织损伤修复和生物电子学提供了一种有前景的水凝胶粘合剂。
