Heo Seyeong, Noh Minhyeok, Kim Yeonseo, Park Sunho
Department of Bio-Industrial Machinery Engineering, Pusan National University, Miryang 50463, Republic of Korea.
ACS Appl Bio Mater. 2025 Jan 20;8(1):62-87. doi: 10.1021/acsabm.4c01427. Epub 2024 Dec 19.
Stem cell-based therapies are emerging as significant approaches in tissue engineering and regenerative medicine, applicable to both fundamental scientific research and clinical practice. Despite remarkable results in clinical studies, challenges such as poor standardization of graft tissues, limited sources, and reduced functionality have hindered the effectiveness of these therapies. In this review, we summarize the engineering approaches involved in fabricating stem cell assisted patches and the substantial strategies for designing stem cell-laden engineered patches (SCP) to complement the existing stem cell-based therapies. We then outline the potential applications of SCP in advancing tissue regeneration and regenerative medicine. By combining living stem cells with engineered patches, SCP can enhance the functions of both components, particularly for tissue engineering applications. Finally, we addressed current challenges, such as ethical considerations, high costs, and regulatory hurdles and proposed future research directions to overcome these barriers.
基于干细胞的疗法正在成为组织工程和再生医学中的重要方法，适用于基础科学研究和临床实践。尽管临床研究取得了显著成果，但诸如移植组织标准化差、来源有限和功能降低等挑战阻碍了这些疗法的有效性。在本综述中，我们总结了制造干细胞辅助贴片所涉及的工程方法以及设计载有干细胞的工程贴片（SCP）以补充现有基于干细胞的疗法的实质性策略。然后，我们概述了SCP在推进组织再生和再生医学方面的潜在应用。通过将活干细胞与工程贴片相结合，SCP可以增强这两种成分的功能，特别是在组织工程应用中。最后，我们讨论了当前的挑战，如伦理考量、高成本和监管障碍，并提出了克服这些障碍的未来研究方向。
