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通过远程医疗为农村地区神经性厌食症提供循证治疗:一项多地点可行性实施研究。

Delivering evidence-based treatment via telehealth for Anorexia Nervosa in rural health settings: a multi-site feasibility implementation study.

作者信息

Hambleton Ashlea, Le Grange Daniel, Kim Marcellinus, Miskovic-Wheatley Jane, Touyz Stephen, Maguire Sarah

机构信息

The InsideOut Institute for Eating Disorders, University of Sydney and Sydney Local Health District, Sydney, NSW, Australia.

Department of Psychiatry and Behavioral Sciences, University of California San Francisco Weill Institute for Neurosciences, School of Medicine, University of California, San Francisco, USA.

出版信息

J Eat Disord. 2024 Dec 19;12(1):207. doi: 10.1186/s40337-024-01175-w.

DOI:10.1186/s40337-024-01175-w
PMID:39702429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11661034/
Abstract

BACKGROUND

Access to evidence-based treatments such as family-based therapy (FBT) is difficult for adolescents diagnosed with Anorexia Nervosa (AN) living in rural or regional areas due to a limited trained workforce, high staff turnover and inconsistent treatment fidelity. Telehealth offers a potential access solution by facilitating care irrespective of family or service location. The disruption to the health system caused by COVID-19 amplified an existing need and increased the use of telehealth to deliver FBT before its efficacy and safety was fully evaluated. This study aimed to evaluate the feasibility, acceptability and preliminary efficacy of telehealth-FBT delivered by community-based clinicians within rural services directly into the home to reduce the eating disorder symptoms of adolescents diagnosed with AN.

METHODS

A pre- and post-implementation multi-site case series delivered up to 20 sessions of telehealth-FBT to 28 adolescents (89.29% female, M = 14.68 ± 1.58 years) living in rural or regional Australia. The RE-AIM framework guided the evaluation, with Reach (treatment uptake and completion); Efficacy (change in weight, global eating disorder symptoms, and remission from baseline to end of treatment and six-month follow-up); Adoption (patient characteristics and drop out); Implementation (intervention fidelity) and Maintenance (outcomes and intervention during the follow-up period) used to assess the feasibility and preliminary efficacy of telehealth-FBT.

RESULTS

There was a high level of interest in telehealth-FBT, with two-thirds of eligible families consenting to participate. Both treatment engagement and completion rates were over 60%, and treatment was delivered with acceptable fidelity. Twenty adolescents (71.43%) met the diagnostic criteria for AN (baseline 86.03%mBMI ± 7.14), and eight (28.57%) for Atypical AN (baseline 101.34%mBMI ± 8.28), with an overall mean duration of illness of 8.53 months (SD = 5.39, range 2-24 months). There was a significant increase in %mBMI at the end of treatment compared to the baseline (p = 0.007, 95%CI: 1.04-6.65), with over 68% of adolescents weight restored and 36.8% of these achieving both weight and psychological remission criteria. Weight remained significantly improved at six-month follow-up (p = 0.005, 95%CI: 1.57-8.65). Also, there was a decrease in adolescents' global eating disorder symptoms, as rated by their parents, at the end of treatment compared to the baseline of 0.735 (p = 0.028, 95%CI: 0.079-1.385).

CONCLUSIONS

Telehealth-FBT was feasibly implemented into rural services and delivered by community clinicians with reach, adoption, preliminary efficacy, and fidelity scores comparable to those reported by specialist studies.

TRIAL REGISTRATION

The study was conducted according to the HREC-approved protocol (HREC 2020/ETH00186) and registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR # 12620001107910).

摘要

背景

对于生活在农村或偏远地区、被诊断患有神经性厌食症(AN)的青少年而言,由于受过培训的工作人员有限、员工流动率高以及治疗保真度不一致,很难获得诸如家庭治疗(FBT)等循证治疗。远程医疗提供了一种潜在的解决方案,无论家庭或服务地点如何,都能促进医疗服务。由新冠疫情导致的卫生系统中断加剧了现有的需求,并在FBT的疗效和安全性得到充分评估之前增加了其远程医疗的使用。本研究旨在评估由农村服务机构的社区临床医生直接上门提供的远程医疗FBT对于减轻被诊断患有AN的青少年饮食失调症状的可行性、可接受性和初步疗效。

方法

在实施前后进行的多地点病例系列研究中,为居住在澳大利亚农村或偏远地区的28名青少年(89.29%为女性,平均年龄M = 14.68 ± 1.58岁)提供了多达20节远程医疗FBT课程。采用RE-AIM框架进行评估,包括覆盖范围(治疗的接受度和完成情况)、疗效(体重变化、整体饮食失调症状以及从基线到治疗结束和六个月随访时的缓解情况)、采用情况(患者特征和退出情况)、实施情况(干预保真度)和维持情况(随访期间的结果和干预),以评估远程医疗FBT的可行性和初步疗效。

结果

对远程医疗FBT的兴趣很高,三分之二符合条件的家庭同意参与。治疗参与率和完成率均超过60%,并且治疗的实施保真度可接受。20名青少年(71.43%)符合AN的诊断标准(基线时平均体重指数mBMI为86.03% ± 7.14),8名(28.57%)符合非典型AN的诊断标准(基线时mBMI为101.34% ± 8.28),总体平均病程为8.53个月(标准差SD = 5.39,范围为2 - 24个月)。与基线相比,治疗结束时mBMI百分比显著增加(p = 0.007,95%置信区间:1.04 - 6.65),超过68%的青少年体重恢复,其中36.8%的青少年达到了体重和心理缓解标准。在六个月随访时体重仍显著改善(p = 0.005,95%置信区间:1.57 - 8.65)。此外,与基线相比,家长评定的青少年整体饮食失调症状在治疗结束时有所减轻,评分为0.735(p = 0.028,95%置信区间:0.079 - 1.385)。

结论

远程医疗FBT已成功在农村服务中实施,由社区临床医生提供,其覆盖范围、采用情况、初步疗效和保真度得分与专业研究报告的相当。

试验注册

本研究按照人类研究伦理委员会(HREC)批准的方案(HREC 2020/ETH00186)进行,并在澳大利亚和新西兰临床试验注册中心(ANZCTR # 12620001107910)注册。

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Eating Disorder Clinical Presentation and Treatment Outcomes by Gender Identity Among Children, Adolescents, and Young Adults.儿童、青少年和青年中按性别认同划分的饮食失调临床表现及治疗结果
J Adolesc Health. 2024 Aug;75(2):254-260. doi: 10.1016/j.jadohealth.2023.11.015. Epub 2024 Feb 4.
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Do People Want the 'New Normal'? A Mixed Method Investigation of Young Person, Parent, and Clinician Experience and Preferences for Eating Disorder Treatment Delivery in the Post-COVID-19 World.
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