基于药代动力学研究的早产儿呼吸暂停静脉注射氨茶碱的给药方案。
Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies.
作者信息
Jones R A, Baillie E
出版信息
Arch Dis Child. 1979 Mar;54(3):190-3. doi: 10.1136/adc.54.3.190.
Abstract
15 preterm infants were treated for recurrent apnoea with theophylline. 5 were given oral choline theophyllinate, but this was erratically absorbed. 14 were given IV aminophylline on 23 occasions. Apparent volume of distribution of theophylline in 12 infants was 0.71 +/- 0.18 1/kg (mean +/- SD). Plasma clearance rate measured in 11 infants at steady state was 18.6 +/- 4.8 ml/kg per hour. Calculations show that a loading dose of 6.2 mg/kg aminophylline intravenously and maintenance of 4.4 mg/kg per day would produce serum levels of between 6 and 12 mg/l in all but one of the infants studied, with no infant having toxic levels.
摘要
15名早产婴儿接受了氨茶碱治疗复发性呼吸暂停。5名婴儿服用了口服胆茶碱，但吸收不稳定。14名婴儿在23次治疗中接受了静脉注射氨茶碱。12名婴儿的氨茶碱表观分布容积为0.71±0.18升/千克（平均值±标准差）。11名处于稳态的婴儿的血浆清除率为每小时18.6±4.8毫升/千克。计算表明，静脉注射6.2毫克/千克氨茶碱的负荷剂量，每天维持4.4毫克/千克，除一名研究婴儿外，所有婴儿的血清水平将在6至12毫克/升之间，且没有婴儿出现中毒水平。
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