Izadi Yazdanabadi Fatemeh, Moghaddam Gholamali, Abbasabadi Mehdi, Akbari Mohsen, Mohammadi Bahram Satlikh, Khosravi Parvin, Sabzekar Hossein, Farrokhi Reza
Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran.
Vet Med Sci. 2025 Jan;11(1):e70171. doi: 10.1002/vms3.70171.
This meta-analysis aimed to evaluate the effects of amino acid supplementation on the growth performance of broiler chicks challenged with coccidiosis. Data were collected on authorship, publication year, study sample characteristics and outcomes of interest related to growth performance. Effect sizes were calculated for both overall effects and the individual effects of each amino acid. The effects of moderator factors, such as supplementation levels and duration, were also assessed, and bias was calculated. Works were obtained from PubMed, Elsevier, ScienceDirect, Wiley, Springer Link and Scopus databases, with the help of search engines like Google Scholar and ResearchGate, covering the period from 2013 to 2023. A random-effects model was used. Thirteen works were included in the current analysis, examining the effects of arginine (n = 4), methionine (n = 6), threonine (n = 3) and glutamine (n = 3). Amino acid supplementation [0.326, CI 95% (0.297-0.355); p = 0.000], arginine [0.430, CI 95% (0.293-0.568); p = 0.000] and threonine [0.793, CI 95% (0.193-1.38); p = 0.009] significantly increased body weight. Amino acid supplementation [0.052, CI 95% (0.022-0.081); p = 0.000] and arginine [0.317, CI 95% (0.049-0.585); p = 0.000] also significantly increased feed intake. Higher levels of amino acids (≥1.50%) and longer supplementation periods (≥15 days) significantly increased body weight and feed intake, while reducing the feed conversion ratio. Funnel plots, fail-safe N and Egger tests showed no evidence of bias. In conclusion, arginine supplementation has the potential to increase body weight and feed intake in poultry challenged with coccidiosis. Higher doses of amino acids and longer supplementation periods are recommended in such cases.
本荟萃分析旨在评估补充氨基酸对受球虫病攻击的肉鸡生长性能的影响。收集了有关作者、出版年份、研究样本特征以及与生长性能相关的感兴趣结果的数据。计算了总体效应以及每种氨基酸的个体效应的效应量。还评估了调节因素（如补充水平和持续时间）的影响，并计算了偏倚。借助谷歌学术和ResearchGate等搜索引擎，从PubMed、爱思唯尔、ScienceDirect、威利、施普林格Link和Scopus数据库中获取了涵盖2013年至2023年期间的文献。使用了随机效应模型。当前分析纳入了13篇文献，研究了精氨酸（n = 4）、蛋氨酸（n = 6）、苏氨酸（n = 3）和谷氨酰胺（n = 3）的影响。补充氨基酸[0.326，95%置信区间（0.297 - 0.355）；p = 0.000]、精氨酸[0.430，95%置信区间（0.293 - 0.568）；p = 0.000]和苏氨酸[0.793，95%置信区间（0.193 - 1.38）；p = 0.009]显著增加了体重。补充氨基酸[0.052，95%置信区间（0.022 - 0.081）；p = 0.000]和精氨酸[0.317，95%置信区间（0.049 - 0.585）；p = 0.000]也显著增加了采食量。较高水平的氨基酸（≥1.50%）和较长的补充期（≥15天）显著增加了体重和采食量，同时降低了饲料转化率。漏斗图、失效安全数N和埃格检验均未显示偏倚证据。总之，补充精氨酸有可能增加受球虫病攻击的家禽的体重和采食量。在这种情况下，建议使用更高剂量的氨基酸和更长的补充期。
