Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine of Porto, University of Porto, Porto, Portugal.
Instituto de Investigação e Inovação em Saúde (I3S), University of Porto, Porto, Portugal.
Eur J Nutr. 2020 Feb;59(1):151-165. doi: 10.1007/s00394-019-01895-9. Epub 2019 Jan 10.
Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model.
Adult male Sprague-Dawley rats (220-310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks.
Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysin rats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin.
Chrysin was able to protect against some of the MS features induced by fructose-feeding.
代谢综合征（MS）是全球主要的公共卫生问题，果糖的摄入与 MS 的发展有关。最近，我们发现膳食多酚白杨素是一种有效的人肠上皮细胞果糖摄取抑制剂。因此，我们的目的是研究白杨素是否会干扰果糖在动物模型中引起的 MS 的发展。
成年雄性 Sprague-Dawley 大鼠（220-310g）随机分为四组：（A）自来水（对照），（B）自来水和口服 100mg/kg 白杨素（白杨素），（C）自来水 10%果糖（果糖），和（D）自来水 10%果糖和口服 100mg/kg 白杨素（果糖+白杨素）。所有组均自由喂食标准实验室饲料，饮食干预持续 18 周。
18 周果糖喂养导致血清三酰甘油、胰岛素和血管紧张素 II 水平升高以及肝纤维化，而在果糖+白杨素组大鼠中则没有发生这些变化。此外，在 14 周开始的果糖喂养动物中观察到的收缩压和舒张压升高，在果糖+白杨素动物中则未观察到。相反，在果糖喂养的大鼠中观察到的能量消耗、肝/体重、心脏/体重和右肾/体重比、血清蛋白、血清瘦素和肝三酰甘油的增加，不受白杨素的影响。
白杨素能够预防果糖喂养引起的部分 MS 特征。
