Mulero Portela Ana L, Colón Santaella Carmen L, Rogers Laura Q, Missaghian Vissepo Mariam
Physical Therapy Program, Medical Science Campus, University of Puerto Rico, P.O. Box 365967, San Juan, Puerto Rico, 00936-5067, USA.
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205, USA.
Support Care Cancer. 2024 Dec 21;33(1):49. doi: 10.1007/s00520-024-09100-2.
Compare the effects of low-intensity and moderate-intensity exercise on physical functioning in breast cancer survivors.
Women aged 50 + years and post-primary treatment for stage 0 to III breast cancer were randomly assigned to a 6-month low-intensity (LIG) or moderate-intensity (MIG) exercise group. Participants were instructed to walk (low- or moderate-intensity) for 30 min five days a week, followed by flexibility exercises, and do strengthening and balance exercises twice weekly. Exercise adherence was facilitated with seven individual counseling sessions tapered over six months and a Theory of Planned Behavior-based booklet. Assessments occurred at baseline, 6 months (post-intervention), and 12 months. Primary measures were PROMIS Physical Functioning, PROMIS Global Health, and six-minute walk test (6MWT).
Of 101 women randomized, 65 (64.4%) completed the study. No statistically significant between-group differences occurred at post-intervention or 12 months. Compared to baseline, within-group improvements in PROMIS physical functioning occurred (LIG increased from 45.87 ± 7.58 to 48.37 ± 7.13 post-intervention (p = 0.01); MIG increased from 45.26 ± 7.27 to 49.53 ± 8.80 post-intervention (p = 0.002) and 48.91 ± 9.29 at 12 months (p = 0.02)). Similarly, Global Health physical health improved (LIG increased from 46.04 ± 5.00 to 49.19 ± 5.76 post-intervention (p = 0.001); MIG increased from 45.06 ± 6.59 to 48.20 ± 7.33 post-intervention (p = 0.005) and 48.49 ± 7.89 at 12 months (p = 0.007)). 6MWT improved between post-intervention and 12 months for the LIG (469.99 ± 64.69 m to 492.19 ± 68.64 m, p = 0.008) and between baseline and post-intervention for the MIG (471.01 ± 62.69 m to 495.88 ± 66.64 m, p = 0.006).
Both low and moderate-intensity exercise led to significant improvement in physical functioning. When feasible and acceptable, prescribing low-intensity exercise can yield important benefits.
ClinicalTrials.gov identifier: NCT02982564.
比较低强度和中等强度运动对乳腺癌幸存者身体机能的影响。
年龄在50岁及以上且处于0至III期乳腺癌初级治疗后的女性被随机分配到6个月的低强度（LIG）或中等强度（MIG）运动组。参与者被指导每周五天进行30分钟的步行（低强度或中等强度），随后进行柔韧性练习，并每周进行两次强化和平衡练习。通过在六个月内逐渐减少的七次个人咨询会议以及一本基于计划行为理论的手册来促进运动依从性。评估在基线、6个月（干预后）和12个月时进行。主要测量指标为患者报告结果测量信息系统（PROMIS）身体机能、PROMIS总体健康以及六分钟步行试验（6MWT）。
在101名随机分组的女性中，65名（64.4%）完成了研究。在干预后或12个月时，组间差异无统计学意义。与基线相比，两组内PROMIS身体机能均有改善（LIG组干预后从45.87±7.58提高到48.37±7.13（p = 0.01）；MIG组干预后从45.26±7.27提高到49.53±8.80（p = 0.002），12个月时为48.91±9.29（p = 0.02））。同样，总体健康中的身体健康也得到改善（LIG组干预后从46.04±5.00提高到49.19±5.76（p = 0.001）；MIG组干预后从45.06±6.59提高到48.20±7.33（p = 0.005），12个月时为48.49±7.89（p = 0.007））。LIG组6MWT在干预后至12个月有所改善（从469.99±64.69米提高到492.19±68.64米，p = 0.008），MIG组在基线至干预后有所改善（从471.01±62.69米提高到495.88±66.64米，p = 0.006）。
低强度和中等强度运动均能显著改善身体机能。在可行且可接受的情况下，开具低强度运动处方可带来重要益处。
ClinicalTrials.gov标识符：NCT02982564。
