James Lija, Hailey Louise H, Suribhatla Rhea, McGagh Dylan, Amarnani Raj, Bundy Christine E, Kirtley Shona, O'Sullivan Denis, Steinkoenig Ingrid, White Jonathan P E, Vivekanantham Arani, Coates Laura C
Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Oriel College, University of Oxford, Oxford, UK.
Ther Adv Musculoskelet Dis. 2024 Dec 22;16:1759720X241295920. doi: 10.1177/1759720X241295920. eCollection 2024.
Psoriatic arthritis (PsA) is a chronic inflammatory condition that can affect individuals of all ages. Patients may experience a range of physical and psychological issues.
To examine the impact of PsA on an individual's quality of life (QoL) and physical function.
A systematic review of the literature.
A comprehensive search was conducted across seven electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, AMED, EMBASE, Global Health, MEDLINE and PsycINFO) to retrieve articles related to QoL and lifestyle in adults with PsA. The inclusion criteria were studies published between 2010 and 2021 that used outcomes validated in patients with PsA. The methodological quality was assessed using Joanna Briggs Institute Critical Appraisal Tools. Our primary outcomes were patient-reported outcomes (PROs) measuring QoL and the impact of disease on physical function. The secondary outcomes were assessments of fatigue, anxiety, depression, sleep, work productivity and employment.
The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. Notably, people with PsA experience reduced health-related quality of life (HRQoL), particularly in emotional, social and mental health aspects. The severity of pain and/or fatigue is directly linked to decreased HRQoL. Importantly, those who fail to achieve minimal disease activity face challenges in work productivity and employment status.
To conclude, our review underscores the significant impact of PsA on patients' HRQoL beyond joint disease. The emotional, social, and mental aspects of PsA require compassionate and holistic management.
The PROSPERO international prospective register of systematic reviews - CRD42021257395.
银屑病关节炎（PsA）是一种可影响所有年龄段个体的慢性炎症性疾病。患者可能会经历一系列身体和心理问题。
研究银屑病关节炎对个体生活质量（QoL）和身体功能的影响。
对文献进行系统综述。
在七个电子数据库（Cochrane对照试验中央注册库（CENTRAL）、护理学与健康领域数据库（CINAHL）、联合和补充医学数据库（AMED）、医学与健康领域数据库（EMBASE）、全球健康数据库、医学期刊数据库（MEDLINE）和心理学文摘数据库（PsycINFO））中进行全面检索，以获取与银屑病关节炎成年患者的生活质量和生活方式相关的文章。纳入标准为2010年至2021年发表的使用在银屑病关节炎患者中验证过的结局指标的研究。使用乔安娜·布里格斯研究所批判性评价工具评估方法学质量。我们的主要结局指标是患者报告结局（PROs），用于衡量生活质量以及疾病对身体功能的影响。次要结局指标是对疲劳、焦虑、抑郁、睡眠、工作效率和就业情况的评估。
该研究纳入了37项全面研究，这些研究考察了银屑病关节炎对生活质量和身体功能的影响。研究结果表明，银屑病关节炎的影响扩展到生活的各个方面，包括日常生活活动、身体和情感方面，如疲劳、睡眠障碍、焦虑和抑郁。值得注意的是，银屑病关节炎患者的健康相关生活质量（HRQoL）下降，尤其是在情感、社会和心理健康方面。疼痛和/或疲劳的严重程度与健康相关生活质量下降直接相关。重要的是，那些未达到最小疾病活动度的患者在工作效率和就业状况方面面临挑战。
总之，我们的综述强调了银屑病关节炎对患者健康相关生活质量的重大影响，其影响超出了关节疾病范畴。银屑病关节炎的情感、社会和心理方面需要给予同情和全面的管理。
国际系统评价前瞻性注册库PROSPERO - CRD42021257395。
