Zhou Guohui, Fu Yuemeng, Chen Jiali, Yang Weiren, Jiao Ning, Jiang Shuzhen, Yuan Xuejun, Li Yang
Key Laboratory of Efficient Utilization of Non-Grain Feed Resources, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an 271017, China.
College of Life Sciences, Shandong Agricultural University, Daizong Street 61, Tai'an 271017, China.
Poult Sci. 2025 Feb;104(2):104698. doi: 10.1016/j.psj.2024.104698. Epub 2024 Dec 19.
A close interplay exists between the gut and liver, known as the "gut-liver axis", which plays a vital role in health and disease. This research aimed to explore the effects of dietary formic acid polymer (FAP) addition on inflammatory injury in gut-liver axis of broilers due to lipopolysaccharide (LPS) challenge. Four hundred and fifty 1-day-old male Arbor Acres broilers were assigned to three treatment groups: (1) control (non-challenged, basal diet); (2) LPS (LPS-challenged, basal diet); (3) LPS+FAP (LPS-challenged, basal diet with 1,000 mg/kg FAP). The trial lasted 21 days. On experimental days 17, 19, and 21, the LPS and LPS+FAP groups were intraperitoneally administered LPS (1 mg/kg BW), and the control group received an equal volume of physiological saline via intraperitoneal injection. Results showed that LPS injection induced inflammatory response, resulted in liver damage, and destroyed intestinal morphology and mucosal barrier. However, dietary FAP supplementation alleviated LPS-induced adverse effects on liver and small intestine by decreasing inflammatory response and suppressing cell death. In conclusion, supplementation of 1000 mg/kg FAP mitigated LPS-induced inflammatory injury in gut-liver axis in broilers.
肠道与肝脏之间存在着密切的相互作用，即所谓的“肠-肝轴”，它在健康和疾病中起着至关重要的作用。本研究旨在探讨添加日粮甲酸聚合物（FAP）对脂多糖（LPS）攻击所致肉鸡肠-肝轴炎症损伤的影响。将450只1日龄雄性艾维茵肉鸡分为三个处理组：（1）对照组（未攻击，基础日粮）；（2）LPS组（LPS攻击，基础日粮）；（3）LPS+FAP组（LPS攻击，添加1000 mg/kg FAP的基础日粮）。试验持续21天。在试验第17、19和21天，LPS组和LPS+FAP组腹腔注射LPS（1 mg/kg体重），对照组腹腔注射等量生理盐水。结果表明，注射LPS诱导了炎症反应，导致肝脏损伤，并破坏了肠道形态和黏膜屏障。然而，日粮中添加FAP通过降低炎症反应和抑制细胞死亡减轻了LPS对肝脏和小肠的不良影响。总之，添加1000 mg/kg FAP减轻了LPS诱导的肉鸡肠-肝轴炎症损伤。
