不同剂量三价表面抗原流感病毒疫苗免疫志愿者后的抗体反应及持久性。
Antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine.
作者信息
Jennings R, Smith T L, Mellersh A R, Clark A, Spencer R C, Potter C W
出版信息
J Hyg (Lond). 1985 Feb;94(1):87-95. doi: 10.1017/s0022172400061167.
Abstract
The serum antibody responses and 50% protective levels (PL50) of antibody were determined, using the SRH test, at one and twelve months post-vaccination in a group of student volunteers immunized with one of three dosages of a trivalent surface-antigen influenza virus vaccine, or with placebo. It was found that, for the H3, H1 and B haemagglutinin components present in the vaccine, a dose of 6 micrograms HA elicited high serum antibody responses at one month post-immunization. High mean antibody levels and a high incidence of volunteers with PL50 values of antibody against each of the HA components of the vaccine remained in the volunteer group twelve months later. The results are discussed in relation to the vaccine dosage used and the nature of the population immunized.
摘要
在一组接种三种不同剂量的三价表面抗原流感病毒疫苗之一或安慰剂的学生志愿者中，在接种疫苗后1个月和12个月时，使用SRH试验测定了血清抗体反应和50%抗体保护水平（PL50）。结果发现，对于疫苗中存在的H3、H1和B血凝素成分，6微克血凝素（HA）的剂量在免疫后1个月引起了较高的血清抗体反应。12个月后，志愿者组中针对疫苗各HA成分的抗体平均水平较高，且具有PL50值的志愿者比例较高。针对所用疫苗剂量和免疫人群的性质对结果进行了讨论。
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