1982/83年流感A（H3N2）现场分离株在一次暴发期间的抗原异质性，采用数值分类学方法进行估计。
Antigenic heterogeneity among influenza A(H3N2) field isolates during an outbreak in 1982/83, estimated by methods of numerical taxonomy.
作者信息
Beyer W E, Masurel N
出版信息
J Hyg (Lond). 1985 Feb;94(1):97-109. doi: 10.1017/s0022172400061179.
Abstract
Fourteen influenza A(H3N2) field isolates, mainly obtained during the first weeks of the 1982/83 influenza epidemic in The Netherlands, and nine influenza A(H3N2) reference strains were examined by means of haemagglutination inhibition (HI) tests with 23 polyclonal ferret sera. The resulting HI patterns were subjected to various methods of numerical taxonomy using, among others, taxonomic distance and correlation between strains for resemblance coefficients. Marked differences between distance and correlation coefficients were found in strains which differed in avidity only. The field isolates could be divided into four groups in respect of their taxonomic resemblance to the reference strains. The same grouping was found for five of the field isolates by testing these against 200 human sera.
摘要
对14株甲型流感病毒H3N2野外分离株（主要是在荷兰1982/83年流感流行的最初几周获得的）和9株甲型流感病毒H3N2参考毒株，使用23份多克隆雪貂血清通过血凝抑制（HI）试验进行检测。所得的HI模式采用多种数值分类法进行分析，这些方法包括分类距离以及菌株间的相关性以得出相似系数。仅在亲和力方面存在差异的菌株，其距离系数和相关系数存在显著差异。就与参考毒株的分类相似性而言，野外分离株可分为四组。通过用200份人血清对其中5株野外分离株进行检测，也发现了相同的分组情况。
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