Ciaccio Edward J, Lee Anne R, Lebovits Jessica, Wolf Randi L, Lewis Suzanne K
Celiac Disease Center at Columbia University Medical Center, Columbia University, New York, NY 10032, United States.
Department of Health Studies and Applied Educational Psychology, Columbia University, Teachers College, New York, NY 10027, United States.
World J Gastrointest Endosc. 2024 Dec 16;16(12):632-639. doi: 10.4253/wjge.v16.i12.632.
Celiac disease is an autoimmune condition that affects approximately 1% of the worldwide community. Originally thought to be confined mostly to the small intestine, resulting in villous atrophy and nutrient malabsorption, it has more recently been implicated in systemic manifestations as well, particularly when undiagnosed or left untreated. Herein, the physical and psychological symptoms of celiac disease are described and explored. An emphasis is placed on efforts to query prospective and confirmed celiac disease patients the use of surveys. Suggestions are made regarding the development of efficacious surveys for the purpose of screening for celiac disease in undiagnosed persons, and monitoring efficacy of the gluten-free diet in persons diagnosed with celiac disease. There are broad categories of physical and psychological symptoms associated with celiac disease. There is also an essential interaction between such physical and the psychological symptoms. It is important to capture the association between symptoms, queries directed toward suspected and confirmed persons with celiac disease. The use of anonymous online surveys can be helpful to determine the qualities and characteristics which may be associated with this condition. It is suggested that personal surveys should be given a greater role in screening and to lessen the time for diagnosis. Querying the subject directly a survey can provide clues as to the types of symptoms being experienced by those with celiac disease currently, as well as to determine the salient aspects of the symptomatology, which will be useful for rapid screening and monitoring in future work.
乳糜泻是一种自身免疫性疾病，全球约1%的人受其影响。最初认为该病主要局限于小肠，会导致绒毛萎缩和营养吸收不良，而最近也发现它与全身表现有关，尤其是在未被诊断或未接受治疗时。本文描述并探讨了乳糜泻的身体和心理症状。重点在于通过调查询问潜在的和确诊的乳糜泻患者。针对为未确诊者筛查乳糜泻以及监测确诊乳糜泻患者无麸质饮食疗效的有效调查的开展提出了建议。乳糜泻有广泛的身体和心理症状类别。这些身体症状和心理症状之间也存在重要的相互作用。了解症状之间的关联很重要，对疑似和确诊的乳糜泻患者进行询问。使用匿名在线调查有助于确定可能与这种疾病相关的特质和特征。建议个人调查在筛查中应发挥更大作用，并缩短诊断时间。通过调查直接询问受试者可以提供有关当前乳糜泻患者所经历症状类型的线索，以及确定症状学的显著方面，这将有助于未来工作中的快速筛查和监测。
