Kleerebezem Michiel, Führen Jori
Department of Animal Sciences, Host Microbe Interactomics Group, Wageningen university and Research, Wageningen 6708 WD, the Netherlands.
Laboratory of Food Microbiology, Wageningen university and Research, Wageningen 6708 WG, the Netherlands.
Microbiome Res Rep. 2024 Sep 4;3(4):46. doi: 10.20517/mrr.2024.48. eCollection 2024.
Synbiotics are defined as "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The definition discriminates between synergistic and complementary synbiotics. Synergistic synbiotics involve a direct interaction between the substrate and co-administered microbe(s), while complementary synbiotics act through independent mechanisms. Here, we evaluate the complexity of discrimination between these two synbiotic concepts using an exemplary study performed with a panel of () strains to identify strain-specific synergistic synbiotics that eventually turned out to work via a complementary synbiotic mechanism. This study highlights that assessing the selectivity of synergistic synbiotics in the intestinal tract is challenging due to the confounding effects of the substrate ingredient on the endogenous microbiome, thereby raising doubts about the added value of distinguishing between synergistic and complementary concepts in synbiotics.
合生元被定义为“一种包含活微生物和宿主微生物选择性利用的底物的混合物，对宿主具有健康益处”。该定义区分了协同型和互补型合生元。协同型合生元涉及底物与共同施用的微生物之间的直接相互作用，而互补型合生元则通过独立机制发挥作用。在此，我们通过一项使用一组（）菌株进行的示范性研究来评估区分这两种合生元概念的复杂性，以识别最终被证明是通过互补型合生元机制起作用的菌株特异性协同型合生元。这项研究强调，由于底物成分对肠道内源性微生物群的混杂影响，评估协同型合生元在肠道中的选择性具有挑战性，从而引发了对区分合生元中协同型和互补型概念的附加价值的质疑。
