Knell Gregory, Hall James R, Large Stephanie, Abdullah Lubnaa, Petersen Melissa, Johnson Leigh A, O'Bryant Sid E
Department of Population & Community Health, College of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Alzheimers Dement. 2025 Jan;21(1):e14322. doi: 10.1002/alz.14322. Epub 2025 Jan 2.
The relationship between Alzheimer's disease (AD) plasma biomarkers, and physical functioning (PF) across diverse races and ethnicities remains unclear. This study aims to explore this association in an ethno-racially diverse sample of cognitively unimpaired community-dwelling adults.
Data clinical examinations, neuropsychological tests, blood draws, and PF exams (Timed Up and Go [TUG] and Short Physical Performance Battery [SPPB]) were analyzed. Multivariable linear regressions assessed the association between PF and AD plasma biomarkers (amyloid beta [Aβ]40, Aβ42, total tau [t-tau], neurofiliament light chain [NfL]).
The sample (n = 2358; mean age 64.7 years; 65.9% female), was 20% African American, 41.9% non-Hispanic White, and 38.1% Hispanic. Findings indicate that worse PF is linked to higher biomarker levels (p < 0.05). Associations differed by race and ethnicity group. TUG time was associated (p < 0.05) with Aβ40, Aβ42, and tau among non-Hispanic Whites, whereas SPPB scores were associated (p < 0.05) with t-tau and NfL among African Americans.
PF, ethnic/racial, and plasma AD biomarker data should be used to aid in developing risk profiles for neurodegenerative diseases.
Alzheimer's disease (AD) biomarkers are associated with physical functioning (PF) Ethno-racial variation exists in AD biomarker and PF associations Race and ethnicity should considered when assessing neurodegenerative disease risk.
阿尔茨海默病（AD）血浆生物标志物与不同种族和族裔的身体功能（PF）之间的关系尚不清楚。本研究旨在探讨认知未受损的社区居住成年人的种族多样化样本中的这种关联。
对临床检查、神经心理学测试、血液检测和PF检查（定时起立行走测试[TUG]和简短体能测试电池[SPPB]）的数据进行了分析。多变量线性回归评估了PF与AD血浆生物标志物（淀粉样蛋白β[Aβ]40、Aβ42、总tau蛋白[t-tau]、神经丝轻链[NfL]）之间的关联。
样本（n = 2358；平均年龄64.7岁；65.9%为女性）中，20%为非裔美国人，41.9%为非西班牙裔白人，38.1%为西班牙裔。研究结果表明，较差的PF与较高的生物标志物水平相关（p < 0.05）。不同种族和族裔群体的关联有所不同。在非西班牙裔白人中，TUG时间与Aβ40、Aβ42和tau蛋白相关（p < 0.05），而在非裔美国人中，SPPB分数与t-tau和NfL相关（p < 0.05）。
PF、种族/族裔和血浆AD生物标志物数据应用于帮助制定神经退行性疾病的风险概况。
阿尔茨海默病（AD）生物标志物与身体功能（PF）相关 AD生物标志物与PF的关联存在种族差异 在评估神经退行性疾病风险时应考虑种族和族裔因素
