Nagashima Yasmin Guerreiro, Soares Aline Alves, Alves Camila Xavier, Medeiros Kleyton Santos, Lopes Marcia Marilia Gomes Dantas, Brandao-Neto Jose
Federal University of Rio Grande do Norte, Natal, Brazil.
Liga Contra o Cancer, Natal, Brazil.
BMJ Open. 2025 Jan 4;15(1):e085631. doi: 10.1136/bmjopen-2024-085631.
Until now, the thyroid cancer case number has increased, and it is not entirely possible to attribute this continuous growth to more meticulous thyroid nodule selection and more accurate diagnostic techniques. While there is currently no conclusive evidence linking dietary factors to thyroid cancer, certain dietary patterns seem to have an impact on the development of the disease. There are interesting connections among diet, environment, metabolism and thyroid carcinogenesis; a deeper comprehension of the underlying mechanisms should help the identification of modifiable risk factors for thyroid cancer. This protocol aims to guide a systematic review and meta-analysis of the literature to search for an association between dietary pattern and risk of thyroid cancer.
The databases to search for observational studies will be PubMed, Embase, Scopus, Web of Science and LILACS, from inception to 10 December 2024. No language limitation or publication period will be imposed. The outcome will be the patients with thyroid cancer. Three impartial reviewers will choose the studies and extract data from the original publications. The Newcastle-Ottawa Quality Scale will assess the risk of bias, and the certainty of the evidence will be achieved by using the Grading of Recommendations Assessment, Development and Evaluation. The R (V.4.3.1) will be performed for data synthesis, and to measure heterogeneity, we will compute the I statistics. Additionally, a quantitative synthesis will be performed if the included studies are sufficiently homogenous.
It is not necessary to acquire ethical approval, as this study will be a review of the published data. A peer-reviewed publication will publish the systematic review's findings.
International Prospective Register of Systematic Reviews (PROSPERO) CRD 42023463802.
到目前为止，甲状腺癌病例数一直在增加，而将这种持续增长完全归因于对甲状腺结节更细致的筛选和更准确的诊断技术并不完全合理。虽然目前尚无确凿证据表明饮食因素与甲状腺癌有关，但某些饮食模式似乎对该疾病的发展有影响。饮食、环境、代谢与甲状腺癌发生之间存在着有趣的联系；对潜在机制的更深入理解应有助于识别甲状腺癌的可改变风险因素。本方案旨在指导对文献进行系统评价和荟萃分析，以寻找饮食模式与甲状腺癌风险之间的关联。
检索观察性研究的数据库将包括PubMed、Embase、Scopus、Web of Science和LILACS，检索时间从建库至2024年12月10日。不设语言限制和出版期限。结局指标为甲状腺癌患者。三名独立评审员将选择研究并从原始出版物中提取数据。将采用纽卡斯尔-渥太华质量量表评估偏倚风险，并通过使用推荐分级的评估、制定和评价来确定证据的确定性。将使用R（V.4.3.1）进行数据合成，为测量异质性，我们将计算I统计量。此外，如果纳入的研究足够同质，将进行定量合成。
由于本研究将对已发表的数据进行综述，因此无需获得伦理批准。系统评价的结果将发表在同行评审的出版物上。
PROSPERO注册号：国际系统评价前瞻性注册库（PROSPERO）CRD 42023463802。
