Ozcinar Beyza, Aribal Erkin, Cabioglu Neslihan, Gurdal Sibel Ozkan, Varol Gamze, Akyurt Nuran, Sezgin Efe, Ozmen Vahit
Department of General Surgery, İstanbul Faculty of Medicine, İstanbul University, İstanbul, 34093, Türkiye.
Department of Radiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, İstanbul, Türkiye.
BMC Womens Health. 2025 Jan 4;25(1):5. doi: 10.1186/s12905-024-03521-1.
The Bahçeşehir population-based mammography screening program (BMSP) is an example of Türkiye's first population-based screening program. This study aims to reveal the successful implementation of population-based secreening program in one of the low- and middle-income countries, Türkiye and long-term results of patients diagnosed with breast cancer during BMSP.
This study was conducted between 2009 and 2019, in the Bahçeşehir county of Istanbul. Women between the ages of 40 and 69 living in this region were invited every two years to undergo clinical breast examination (CBE) and mammography screening. All data was recorded in a dedicated software program. Women diagnosed with breast cancer were followed as a separate cohort.
During the 10-year screening period, 8,825 women were screened and 146 (1.7%) breast cancers were detected. The median age at diagnosis for these patients was 52.9 years (40-69). The risk of breast cancer was 1.39 times higher (95% CI: 1.01-1.93) in women aged ≥ 50 compared to those less than 50 years (p = 0.045). The Cox regression analysis revealed that age at first birth, and number of births were significant predictors of breast cancer risk (p < 0.001, and p = 0.011). The breast cancer rate tends to increase as the breast density category progresses from A to D (p < 0.001). The median follow-up time for 146 breast cancer patients was 95.3 months. The 10-year breast cancer specific survival rate was 85%.
This study demonstrates that with a committed team and sufficient infrastructure, screening mammography can be effectively carried out in Türkiye, leading to early detection and lower mortality rates. The recommended age to commence screening is 40 years old.
巴赫切希尔基于人群的乳腺钼靶筛查项目（BMSP）是土耳其首个基于人群的筛查项目。本研究旨在揭示在土耳其这个低收入和中等收入国家之一成功实施基于人群的筛查项目情况，以及BMSP期间被诊断为乳腺癌患者的长期结果。
本研究于2009年至2019年在伊斯坦布尔的巴赫切希尔县进行。居住在该地区年龄在40至69岁之间的女性每两年被邀请接受临床乳腺检查（CBE）和乳腺钼靶筛查。所有数据记录在一个专用软件程序中。被诊断为乳腺癌的女性作为一个单独队列进行随访。
在10年的筛查期间，8825名女性接受了筛查，检测出146例（1.7%）乳腺癌。这些患者诊断时的中位年龄为52.9岁（40 - 69岁）。≥50岁的女性患乳腺癌的风险比小于50岁的女性高1.39倍（95%置信区间：1.01 - 1.93）（p = 0.045）。Cox回归分析显示，初产年龄和生育次数是乳腺癌风险的重要预测因素（p < 0.001和p = 0.011）。随着乳腺密度类别从A到D进展，乳腺癌发病率呈上升趋势（p < 0.001）。146例乳腺癌患者的中位随访时间为95.3个月。10年乳腺癌特异性生存率为85%。
本研究表明，有了敬业的团队和充足的基础设施，乳腺钼靶筛查在土耳其可以有效开展，从而实现早期发现并降低死亡率。建议开始筛查的年龄为40岁。
