Amjadi Arezoo, Abbasi Mobarakeh Khadijeh, Doaei Saeid, Dorosti Masoumeh, Nami Sheyda, Mirshafaei Seyed Reza, Mirshafaei Masoomeh Alsadat, Ataei Kachooei Masoomeh, Shamsi-Goushki Ali, Saeedirad Zahra, Azizi Tabesh Ghasem, Khoshdooz Sara, Abdollahi Morteza, Shekari Soheila, Gholamalizadeh Maryam
Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
J Nutr Sci. 2024 Nov 27;13:e75. doi: 10.1017/jns.2024.55. eCollection 2024.
Spontaneous abortion (SA) is considered one of the most prevalent adverse outcomes of pregnancy. SA may occur due to genetic susceptibility and various maternal factors such as nutritional status. The aim of this study was to assess how dietary carotenoids and the gene are related to SA. This case-control study included 192 women with a history of SA as the case group and 347 healthy women without history of SA as the control group. To evaluate carotenoid intake, a valid 168-item food frequency questionnaire (FFQ) was used. The gene was genotyped for the presence of the polymorphism using the tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR). The results indicated a significant negative association between dietary intake of β-cryptoxanthin and SA in carriers of the TT genotype of the polymorphism after adjustment for age, BMI, physical activity, smoking, alcohol drinking, and calorie intake (β = -0.28, P = 0.02). No association was found between SA with dietary intake of beta-carotene, alpha-carotene, lutein, and lycopene among carriers of different genotypes. The genotype may have an effect on the association between SA and carotenoid intake. Dietary intake of β-cryptoxanthin may act as a protective factor against SA only in carriers of the TT genotype of the polymorphism.
自然流产（SA）被认为是妊娠最常见的不良结局之一。SA可能由于遗传易感性和各种母体因素如营养状况而发生。本研究的目的是评估膳食类胡萝卜素与[某基因]如何与SA相关。这项病例对照研究包括192名有SA病史的女性作为病例组和347名无SA病史的健康女性作为对照组。为了评估类胡萝卜素的摄入量，使用了一份有效的168项食物频率问卷（FFQ）。使用四引物扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）对[某基因]进行基因分型以检测[某多态性]的存在。结果表明，在调整年龄、体重指数、身体活动、吸烟、饮酒和热量摄入后，β-隐黄质的膳食摄入量与[某多态性]TT基因型携带者的SA之间存在显著负相关（β = -0.28，P = 0.02）。在不同[某基因]基因型携带者中，未发现SA与β-胡萝卜素、α-胡萝卜素、叶黄素和番茄红素的膳食摄入量之间存在关联。[某基因]基因型可能对SA与类胡萝卜素摄入量之间的关联有影响。仅在[某多态性]TT基因型携带者中，β-隐黄质的膳食摄入量可能作为SA的保护因素。
