• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多种菌株混合物的累加效应，结合了单一菌株对人类肠道微生物群的影响。

Additive effect of mixtures of multiple strains combining the effects of single strains on human gut microbiota .

作者信息

Tsujikawa Yuji, Yamamoto Junya, Fukuda Itsuko, Sakane Iwao

机构信息

Central Research Institute, Itoen Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, Japan.

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.

出版信息

Biosci Microbiota Food Health. 2025;44(1):58-69. doi: 10.12938/bmfh.2024-059. Epub 2024 Aug 21.

DOI:10.12938/bmfh.2024-059
PMID:39764492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11700551/
Abstract

Probiotics exert their beneficial effects by improving the intestinal environment. Heat-inactivated probiotics may show similar effects. However, whether multi-strain mixtures (MSM) are better than single strains, irrespective of whether the bacteria are alive or dead, is unknown. In this study, we examined the gut-improving efficacy of an MSM consisting of four dead bacterial strains using an model that simulates the human gut environment. In the model, human feces were inoculated with a single-strain or MSM, and the microbial composition and fermentation products were assessed. The 16S rRNA gene sequences showed that the MSM tended to change the microbial community structure more than single strains. Furthermore, the results of a microbial diversity analysis showed that despite differences among single strains, the effect of the MSM increased with the abundance of any single strain. A similar trend was observed for fermentation products. These results suggested that the MSM made from dead bacteria exerted additive effects that may provide new health benefits to more people.

摘要

益生菌通过改善肠道环境发挥其有益作用。热灭活的益生菌可能表现出类似的效果。然而，无论细菌是活的还是死的，多菌株混合物（MSM）是否比单一菌株更好尚不清楚。在本研究中，我们使用模拟人类肠道环境的模型，研究了由四种死菌株组成的MSM改善肠道的功效。在该模型中，将人类粪便接种单一菌株或MSM，并评估微生物组成和发酵产物。16S rRNA基因序列显示，与单一菌株相比，MSM更倾向于改变微生物群落结构。此外，微生物多样性分析结果表明，尽管单一菌株之间存在差异，但MSM的效果随着任何单一菌株丰度的增加而增强。发酵产物也观察到类似趋势。这些结果表明，由死细菌制成的MSM发挥了累加效应，可能为更多人提供新的健康益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/d14d29a87b83/bmfh-44-058-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/72185bcf6381/bmfh-44-058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/2ca3f777271a/bmfh-44-058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/bc80b5b4b39e/bmfh-44-058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/7c3d7f698a2f/bmfh-44-058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/84f6db2eac12/bmfh-44-058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/0cdec75c6cce/bmfh-44-058-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/a7696360c733/bmfh-44-058-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/b968afbdeb6b/bmfh-44-058-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/dd7cb03497fd/bmfh-44-058-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/d14d29a87b83/bmfh-44-058-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/72185bcf6381/bmfh-44-058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/2ca3f777271a/bmfh-44-058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/bc80b5b4b39e/bmfh-44-058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/7c3d7f698a2f/bmfh-44-058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/84f6db2eac12/bmfh-44-058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/0cdec75c6cce/bmfh-44-058-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/a7696360c733/bmfh-44-058-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/b968afbdeb6b/bmfh-44-058-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/dd7cb03497fd/bmfh-44-058-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2639/11700551/d14d29a87b83/bmfh-44-058-g010.jpg

相似文献

1
Additive effect of mixtures of multiple strains combining the effects of single strains on human gut microbiota .多种菌株混合物的累加效应，结合了单一菌株对人类肠道微生物群的影响。
Biosci Microbiota Food Health. 2025;44(1):58-69. doi: 10.12938/bmfh.2024-059. Epub 2024 Aug 21.
2
Dairy-based multi-strain probiotic community successfully mitigated obesity-related gut microbiota dysbiosis (CoMiniGut).基于乳制品的多菌株益生菌群落成功缓解了肥胖相关的肠道微生物群落失调（CoMiniGut）。
J Med Microbiol. 2024 Nov;73(11). doi: 10.1099/jmm.0.001936.
3
Administration of two probiotic strains during early childhood does not affect the endogenous gut microbiota composition despite probiotic proliferation.在儿童早期给予两种益生菌菌株，尽管益生菌会增殖，但不会影响内源性肠道微生物群的组成。
BMC Microbiol. 2017 Aug 17;17(1):175. doi: 10.1186/s12866-017-1090-7.
4
A specific blend of prebiotics and postbiotics improved the gut microbiome of dogs with soft stools in the in vitro Simulator of the Canine Intestinal Microbial Ecosystem.在犬肠道微生物生态系统体外模拟器中，一种特定的益生元与后生元混合物改善了软便犬的肠道微生物群。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf056.
5
Matrix Effects on the Delivery Efficacy of Bifidobacterium animalis subsp. BB-12 on Fecal Microbiota, Gut Transit Time, and Short-Chain Fatty Acids in Healthy Young Adults.双歧杆菌 BB-12 对健康年轻成年人粪便微生物群、肠道转运时间和短链脂肪酸的传递效果的基质效应。
mSphere. 2021 Aug 25;6(4):e0008421. doi: 10.1128/mSphere.00084-21. Epub 2021 Jul 7.
6
Compound probiotics can improve intestinal health by affecting the gut microbiota of broilers.复合益生菌可通过影响肉鸡的肠道微生物群来改善肠道健康。
J Anim Sci. 2023 Jan 3;101. doi: 10.1093/jas/skad388.
7
Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection.高风险男男性行为人群的肠道微生物群可驱动无菌小鼠的免疫激活和体外 HIV 感染。
PLoS Pathog. 2019 Apr 4;15(4):e1007611. doi: 10.1371/journal.ppat.1007611. eCollection 2019 Apr.
8
Treatment with mixed probiotics induced, enhanced and diversified modulation of the gut microbiome of healthy rats.混合益生菌治疗可诱导、增强和多样化健康大鼠肠道微生物组的调节。
FEMS Microbiol Ecol. 2021 Dec 1;97(12). doi: 10.1093/femsec/fiab151.
9
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities.遗传型性腺功能减退症小鼠模型揭示了生殖轴和性别对肠道微生物群落的特定小生境影响。
Biol Sex Differ. 2023 Nov 6;14(1):79. doi: 10.1186/s13293-023-00564-1.
10
Effect of potato fiber on survival of Lactobacillus species at simulated gastric conditions and composition of the gut microbiota in vitro.马铃薯纤维对模拟胃液条件下乳酸菌属生存的影响及体外肠道微生物组的组成。
Food Res Int. 2019 Nov;125:108644. doi: 10.1016/j.foodres.2019.108644. Epub 2019 Aug 24.

引用本文的文献

1
The alleviating effects and mechanisms of Kimate-X and Kimate-F combination on canine inflammatory bowel disease.Kimate-X与Kimate-F联合用药对犬炎症性肠病的缓解作用及机制
Front Vet Sci. 2025 May 6;12:1534665. doi: 10.3389/fvets.2025.1534665. eCollection 2025.

本文引用的文献

1
Isolation and identification of hyaluronan-degrading bacteria from Japanese fecal microbiota.从日本粪便微生物群中分离和鉴定透明质酸降解菌。
PLoS One. 2023 May 17;18(5):e0284517. doi: 10.1371/journal.pone.0284517. eCollection 2023.
2
Probiotic-Based Bacteriocin: Immunity Supplementation Against Viruses. An Updated Review.基于益生菌的细菌素：针对病毒的免疫补充。最新综述。
Front Microbiol. 2022 Jul 26;13:876058. doi: 10.3389/fmicb.2022.876058. eCollection 2022.
3
alleviates intestinal inflammation and promotes microbiota-mediated protection against fatal infections.
缓解肠道炎症，促进微生物群介导的抗感染保护作用。
Front Immunol. 2022 Aug 11;13:973224. doi: 10.3389/fimmu.2022.973224. eCollection 2022.
4
Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages.普雷沃氏菌科通过 PPARα-CYP4X1 轴在结肠巨噬细胞中产生丁酸盐来缓解 PD-1/PD-L1 抑制剂相关的心脏毒性。
J Exp Clin Cancer Res. 2022 Jan 3;41(1):1. doi: 10.1186/s13046-021-02201-4.
5
Uremic Toxins and Vascular Dysfunction.尿毒症毒素与血管功能障碍
Toxins (Basel). 2020 Jun 18;12(6):404. doi: 10.3390/toxins12060404.
6
Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - their chemical structure and biological attributes.双歧杆菌细胞壁衍生的胞外多糖、脂磷壁酸、肽聚糖、极性脂类和蛋白质 - 它们的化学结构和生物学特性。
Int J Biol Macromol. 2020 Mar 15;147:333-349. doi: 10.1016/j.ijbiomac.2019.12.227. Epub 2019 Dec 30.
7
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.为您的患者选择合适的益生菌产品：基于证据的实用指南。
PLoS One. 2018 Dec 26;13(12):e0209205. doi: 10.1371/journal.pone.0209205. eCollection 2018.
8
Effects of paraprobiotic MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults.补充拟杆菌 MCC1849 对健康成年人普通感冒症状和情绪状态的影响。
Benef Microbes. 2018 Dec 7;9(6):855-864. doi: 10.3920/BM2017.0197. Epub 2018 Aug 13.
9
Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial.热灭活乳球菌 JCM 5805 对男性运动员连续高强度运动中免疫和疲劳的影响：一项随机、安慰剂对照、双盲试验。
J Int Soc Sports Nutr. 2018 Aug 2;15(1):39. doi: 10.1186/s12970-018-0244-9.
10
Para-probiotics for Preterm Neonates-The Next Frontier.早产儿的后生元——下一个前沿。
Nutrients. 2018 Jul 5;10(7):871. doi: 10.3390/nu10070871.