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光生物调节对牙周炎小鼠模型氧化和炎症反应的调节作用

Modulatory Effects of Photobiomodulation on Oxidative and Inflammatory Responses in a Murine Model of Periodontitis.

作者信息

Braga Larissa Trarbach Figueiredo, Ribeiro Isadora Martins, Barroso Maria Eduarda de Souza, Kampke Edgar Hell, Neves Lorena Nascimento Santos, Andrade Sara Cecília, Barbosa Guilherme Heleodoro, Porto Marcella Leite, Meyrelles Silvana Santos

机构信息

Graduate Program of Dental Sciences, Federal University of Espirito Santo (UFES), Av. Marechal Campos, 1468, Maruípe, Vitória 29043-900, ES, Brazil.

Graduate Program of Physiological Sciences, Federal University of Espirito Santo (UFES), Av. Marechal Campos, 1468, Maruípe, Vitória 29043-900, ES, Brazil.

出版信息

Antioxidants (Basel). 2024 Nov 26;13(12):1450. doi: 10.3390/antiox13121450.

DOI:10.3390/antiox13121450
PMID:39765779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11672657/
Abstract

Periodontitis, an oral disease initiated by a dysbiotic dental biofilm, has an unclear response to photobiomodulation (PBM) as an adjunctive treatment. This study investigates the effects of PBM on reactive oxygen species (ROS), apoptosis, oxidative stress, and inflammatory markers in a periodontitis model using C57BL/6 mice, divided into four groups: control (C), control + PBM (C + PBM), periodontitis (P), and periodontitis + PBM (P + PBM). An infrared diode laser (808 nm, 133.3 J/cm, 4 J/session) was applied for three days. PBM reduced superoxide anions, hydrogen peroxide, and apoptosis in gingival cells, while decreasing systemic inflammation and protein oxidation. In the P + PBM group, pro-inflammatory cytokines IL-6 and IL-12p70 decreased, whereas IL-10 increased, suggesting improvements in oxidative stress and inflammation profiles.

摘要

牙周炎是一种由生态失调的牙菌斑引发的口腔疾病，作为辅助治疗手段，其对光生物调节（PBM）的反应尚不清楚。本研究使用C57BL/6小鼠牙周炎模型，将其分为四组：对照组（C）、对照+PBM组（C + PBM）、牙周炎组（P）和牙周炎+PBM组（P + PBM），研究PBM对活性氧（ROS）、细胞凋亡、氧化应激和炎症标志物的影响。使用红外二极管激光（808 nm，133.3 J/cm，4 J/次）照射三天。PBM可减少牙龈细胞中的超氧阴离子、过氧化氢和细胞凋亡，同时减轻全身炎症和蛋白质氧化。在P + PBM组中，促炎细胞因子IL-6和IL-12p70减少，而IL-10增加，表明氧化应激和炎症状况有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/0cd459d6df79/antioxidants-13-01450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/fdfcbcf373cf/antioxidants-13-01450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/dab02519c627/antioxidants-13-01450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/1f2dfddf55cd/antioxidants-13-01450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/0cd459d6df79/antioxidants-13-01450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/fdfcbcf373cf/antioxidants-13-01450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/dab02519c627/antioxidants-13-01450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/1f2dfddf55cd/antioxidants-13-01450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ca8/11672657/0cd459d6df79/antioxidants-13-01450-g004.jpg

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2
Unraveling the RAGE-NF-κB pathway: implications for modulating inflammation in diabetic neuropathy through photobiomodulation therapy.揭示 RAGE-NF-κB 通路：光生物调节疗法在通过调节糖尿病神经病变中的炎症反应中的作用。
Lasers Med Sci. 2024 Aug 22;39(1):222. doi: 10.1007/s10103-024-04171-3.
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Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.
免疫细胞在慢性牙周炎中的因果作用：一项双向孟德尔随机化研究
BMC Oral Health. 2024 Jul 16;24(1):806. doi: 10.1186/s12903-024-04592-0.
4
Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies.牙周炎及相关系统性疾病中的线粒体功能障碍：对发病机制和治疗策略的影响。
Int J Mol Sci. 2024 Jan 13;25(2):1024. doi: 10.3390/ijms25021024.
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Photobiomodulation effects on fibroblasts and keratinocytes after ionizing radiation and bacterial stimulus.辐照和细菌刺激后光生物调节对成纤维细胞和角质形成细胞的影响。
Arch Oral Biol. 2024 Mar;159:105874. doi: 10.1016/j.archoralbio.2023.105874. Epub 2023 Dec 16.
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The effect of bone remodeling with photobiomodulation in dentistry: a review study.光生物调节对牙科中骨重塑的影响：综述研究。
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