Saito Mika, Ginszt Michał, Massidda Myosotis, Cięszczyk Paweł, Okamoto Takanobu, Majcher Piotr, Nakazato Koichi, Kikuchi Naoki
Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Department of Rehabilitation and Physiotherapy, Medical University of Lublin, Poland.
Biol Sport. 2021 Jun;38(2):229-234. doi: 10.5114/biolsport.2020.98624. Epub 2020 Sep 4.
Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene is associated with athletic performance and physiological phenotypes. The purpose of this study was to investigate the frequency of MCT1 T1470A polymorphism in Polish and Japanese climbers using a case-control study. Our sample consisted of 226 climbers (Japanese: n = 100, 64 male and 36 female; Polish: n = 126, 97 male and 29 female) and 1028 non-athletic controls (Japanese, n = 407; Polish = 621) who were genotyped for the MCT1 T1470A polymorphism (rs1049434) using the TaqMan SNP genotyping assay or restriction enzyme. The frequency of the TT genotype and T allele was significantly higher in climbers than in controls among the Polish subjects (genotype: p = 0.030, allele: p = 0.010); however, there were no significant differences in the genotype and allelic frequencies between the Japanese climbers and controls (genotype: p = 0.968; allele: p = 0.803). Our results suggested that the frequency of the T allele (TT+TA genotype) in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. In addition, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls.
竞技攀岩将成为2020年东京奥运会的正式比赛项目；它是一项在运动员和业余爱好者中都很受欢迎的野外运动。我们之前的研究表明，单羧酸转运蛋白1（MCT1）基因的T1470A多态性（rs1049434）与运动表现和生理表型有关。本研究的目的是通过病例对照研究调查波兰和日本攀岩者中MCT1 T1470A多态性的频率。我们的样本包括226名攀岩者（日本人：n = 100，男性64名，女性36名；波兰人：n = 126，男性97名，女性29名）和1028名非运动员对照（日本人，n = 407；波兰人 = 621），使用TaqMan SNP基因分型检测法或限制性内切酶对MCT1 T147A多态性（rs1049434）进行基因分型。在波兰受试者中，攀岩者的TT基因型和T等位基因频率显著高于对照组（基因型：p = 0.030，等位基因：p = 0.010）；然而，日本攀岩者与对照组之间的基因型和等位基因频率没有显著差异（基因型：p = 0.968；等位基因：p = 0.803）。我们的结果表明，MCT1 T1470A多态性中T等位基因（TT + TA基因型）的频率在波兰攀岩者中过高，但在日本攀岩者中并非如此。此外，波兰男子攀岩者中T等位基因和TT基因型的频率高于对照组。
