Air Pollution's Hidden Toll: Links Between Ozone, Particulate Matter, and Adolescent Depression.

Rising rates of depression among youth present a growing mental health crisis. Despite growing concerns regarding the risks of air pollution exposure on youth mental and physical health, associations between ambient air pollutants and depression have been largely overlooked in youth. In this cross-sectional study, we investigated associations between ozone, particulate matter, and depressive symptoms in adolescents across 224 Colorado census tracts (average age of 14.45 years, 48.8% female, 48.9% of minority race/ethnicity). Students in participating schools reported depressive symptoms and demographic information, and school addresses were used to compute ozone and particulate matter levels per census tract. Possible confounding variables, including sociodemographic and geographic characteristics, were also addressed. Exploratory analyses examined demographic moderators of these associations. Census tracts with higher ozone concentrations had a higher percentage of adolescents experiencing depressive symptoms. Particulate matter did not emerge as a significant predictor of adolescent depressive symptoms. Secondary analyses demonstrated that associations with ozone were moderated by racial/ethnic and gender compositions of census tracts, with stronger effects in census tracts with higher percentages of individuals with marginalized racial/ethnic and gender identities. Ultimately, this project strengthens our understanding of the interplay between air pollution exposures and mental health during adolescence.