外泌体作为心血管疾病中巨噬细胞的调节因子

Exosomes as Regulators of Macrophages in Cardiovascular Diseases.

作者信息

Soriano-Cruz Marina, Vázquez-González Wendy Guadalupe, Molina-Vargas Paula, Faustino-Trejo Alejandro, Chávez-Rueda Adriana Karina, Legorreta-Haquet María Victoria, Aguilar-Ruíz Sergio Roberto, Chávez-Sánchez Luis

机构信息

Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.

Unidad de Investigación Médica en Enfermedades Metabólicas, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.

出版信息

Biomedicines. 2024 Nov 25;12(12):2683. doi: 10.3390/biomedicines12122683.

DOI:10.3390/biomedicines12122683

PMID:39767590

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11726971/

Abstract

Macrophages in atherosclerosis and myocardial infarction have diverse functions, such as foam cell formation and the induction of an inflammatory response that promotes ventricular dysfunction in the heart. Exosomes are small vesicles released by many different types of cells, such as macrophages, dendritic cells, platelets and other immunoregulatory cells, that facilitate communication with other cells, modulating the biological functions of recipient cells. Exosomes offer a novel therapeutic approach for the polarization of macrophages involved in cardiovascular diseases. In this review, we provide an overview of the biological role of macrophages in atherosclerosis and myocardial infarction and the effects of exosomes on these cells as therapeutic agents in the disease.

摘要

巨噬细胞在动脉粥样硬化和心肌梗死中具有多种功能，如形成泡沫细胞以及诱导炎症反应，进而促进心脏心室功能障碍。外泌体是由许多不同类型的细胞释放的小囊泡，如巨噬细胞、树突状细胞、血小板和其他免疫调节细胞，它们有助于与其他细胞进行通讯，调节受体细胞的生物学功能。外泌体为参与心血管疾病的巨噬细胞极化提供了一种新的治疗方法。在这篇综述中，我们概述了巨噬细胞在动脉粥样硬化和心肌梗死中的生物学作用，以及外泌体作为疾病治疗剂对这些细胞的影响。