Wilpizeski C R, Lowry L D, el Raheb M, Eyyunni U, Contrucci R B, Goldman W S
Am J Otolaryngol. 1985 Jan-Feb;6(1):1-22. doi: 10.1016/s0196-0709(85)80002-8.
Under a variety of experimental conditions, nonrestrained adult male squirrel monkeys were subjected to continuous rotation in the horizontal plane at 33 rpm. Severity of motion-induced sickness was quantified by measuring latencies of three responses associated with sickness. Per- and postrotational nystagmus was recorded from a subsample of monkeys with permanent recording electrodes implanted in the bony orbits. Incidence of sickness depended on the time limits of stimulation imposed, and it occurred in a maximum of about 90 per cent of test sessions if rotation was continued for two hours. When subjected to ten once-per-day rotation sessions, only a few monkeys showed evidence of developing transient habituation of onset of motion sickness. Mean frequency of emetic episodes, however, declined over the latter half of the rotation series. Restricting visual cues by blindfolding the monkeys prevented most subjects from vomiting.
在各种实验条件下，对未受束缚的成年雄性松鼠猴施加33转/分钟的水平连续旋转。通过测量与疾病相关的三种反应的潜伏期来量化运动诱发疾病的严重程度。对在眼眶骨中植入永久性记录电极的猴子子样本记录旋转前后的眼球震颤。疾病发生率取决于施加刺激的时间限制，如果旋转持续两小时，在最多约90%的测试时段中会发生。当进行每天一次共十次的旋转实验时，只有少数猴子表现出运动病发作出现短暂习惯化的迹象。然而，呕吐发作的平均频率在旋转系列的后半段有所下降。通过蒙住猴子的眼睛来限制视觉线索可防止大多数实验对象呕吐。
