Shinba Toshikazu, Fujita Yusuke, Ogawa Yusuke, Shinba Yujiro, Shinba Shuntaro
Department of Psychiatry, Shizuoka Saiseikai General Hospital, Shizuoka 422-8527, Japan.
Research Division, Saiseikai Research Institute of Health Care and Welfare, Tokyo 108-0073, Japan.
Sensors (Basel). 2024 Dec 19;24(24):8097. doi: 10.3390/s24248097.
(1) Background: Delirium is a serious condition in patients undergoing treatment for somatic diseases, leading to poor prognosis. However, the pathophysiology of delirium is not fully understood and should be clarified for its adequate treatment. This study analyzed the relationship between confusion symptoms in delirium and resting-state electroencephalogram (EEG) power spectrum (PS) profiles to investigate the heterogeneity. (2) Methods: The participants were 28 inpatients in a general hospital showing confusion symptoms with an Intensive Care Delirium Screening Checklist (ICDSC) score of 4 or above. EEG was measured at Pz in the daytime awake state for 100 s with the eyes open and 100 s with the eyes closed on the day of the ICDSC evaluation. PS analysis was conducted consecutively for each 10 s datum. (3) Results: Two resting EEG PS patterns were observed regarding the dominant rhythm: the presence or absence of a dominant rhythm, whereby the PS showed alpha or theta peaks in the former and no dominant rhythm in the latter. The patients showing a dominant EEG rhythm were frequently accompanied by hallucination or delusion ( = 0.039); conversely, those lacking a dominant rhythm tended to exhibit fluctuations in the delirium symptoms ( = 0.020). The other ICDSC scores did not differ between the participants with these two EEG patterns. (4) Discussion: The present study indicates that the presence and absence of a dominant EEG rhythm in delirious patients are related to different symptoms of delirium. Using EEG monitoring in the care of delirium will help characterize its heterogeneous pathophysiology, which requires multiple management strategies.
(1) 背景：谵妄是躯体疾病治疗患者中的一种严重情况，会导致预后不良。然而，谵妄的病理生理学尚未完全明了，为了进行充分治疗，需要对其加以阐明。本研究分析了谵妄中的意识模糊症状与静息态脑电图（EEG）功率谱（PS）特征之间的关系，以探究其异质性。(2) 方法：研究对象为一家综合医院的28名住院患者，这些患者表现出意识模糊症状，重症监护谵妄筛查检查表（ICDSC）评分在4分及以上。在ICDSC评估当天，于白天清醒状态下，在Pz电极处测量脑电图，睁眼状态下测量100秒，闭眼状态下测量100秒。对每10秒的数据连续进行PS分析。(3) 结果：关于主导节律，观察到两种静息脑电图PS模式：存在或不存在主导节律，在前一种情况下PS显示α或θ峰值，在后一种情况下不存在主导节律。脑电图显示主导节律的患者经常伴有幻觉或妄想（P = 0.039）；相反，缺乏主导节律的患者谵妄症状往往有波动（P = 0.020）。这两种脑电图模式的参与者之间，其他ICDSC评分没有差异。(4) 讨论：本研究表明，谵妄患者中脑电图主导节律的存在与否与谵妄的不同症状相关。在谵妄护理中使用脑电图监测将有助于表征其异质性病理生理学，这需要多种管理策略。
