Kim Seung Bhin, Bong Su Hyun, Lee Jong Hun, Choi Tae Young, Yoon Seo Young, Kim Jun Won
Department of Psychiatry, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.
Psychiatry Investig. 2023 Feb;20(2):144-151. doi: 10.30773/pi.2022.0294. Epub 2023 Feb 23.
Incontrovertible disease markers are absent in delirium. This study investigated the usefulness of quantitative electroencephalography (qEEG) in diagnosing delirium.
This retrospective case-control study reviewed medical records and qEEG data of 69 age/sex-matched patients (delirium group, n=30; control group, n=39). The first minute of artifact-free EEG data with eyes closed was selected. Nineteen electrodes' sensitivity, specificity, and correlation with delirium rating scale-revised-98 were analyzed.
On comparing the means of absolute power by frontal, central, and posterior regions, the delta and theta powers showed significant differences (p<0.001) in all regions, and the magnitude of the absolute power was higher in the delirium group than in the control group; only the posterior region showed a significant (p<0.001) difference in beta power. The spectral power of theta at the frontal region (area under the curve [AUC]=0.84) and theta at the central and posterior regions (AUC=0.83) showed 90% sensitivity and 79% specificity, respectively, in differentiating delirious patients and controls. The beta power of the central region showed a significant negative correlation with delirium severity (R=-0.457, p=0.011).
Power spectrum analysis of qEEG showed high accuracy in screening delirium among patients. The study suggests qEEG as a potential aid in diagnosing delirium.
谵妄缺乏确凿的疾病标志物。本研究调查了定量脑电图（qEEG）在诊断谵妄中的实用性。
这项回顾性病例对照研究回顾了69例年龄/性别匹配患者（谵妄组，n = 30；对照组，n = 39）的病历和qEEG数据。选取闭眼无伪迹脑电图数据的第一分钟。分析了19个电极的敏感性、特异性以及与谵妄评定量表修订版98的相关性。
比较额叶、中央区和后区的绝对功率均值，δ波和θ波功率在所有区域均显示出显著差异（p<0.001），且谵妄组的绝对功率幅度高于对照组；仅后区在β波功率上显示出显著差异（p<0.001）。额叶区域的θ波频谱功率（曲线下面积[AUC]=0.84）以及中央区和后区的θ波频谱功率（AUC=0.83）在区分谵妄患者和对照组时，敏感性分别为90%，特异性分别为79%。中央区的β波功率与谵妄严重程度呈显著负相关（R=-0.457，p=0.011）。
qEEG的功率谱分析在筛查患者谵妄方面显示出较高的准确性。该研究表明qEEG可作为诊断谵妄的潜在辅助手段。
