Marti Melanie, Nohynek Hanna, Duclos Philippe, O'Brien Katherine L, Hombach Joachim
Department of Immunization, Vaccines and Biologicals, World Health Organization, CH-1211 Geneva, Switzerland.
Finnish Institute for Health and Welfare, 00271 Helsinki, Finland.
Vaccines (Basel). 2024 Dec 12;12(12):1402. doi: 10.3390/vaccines12121402.
BACKGROUND/OBJECTIVES: In November 1999, WHO established the Strategic Advisory Group of Experts (SAGE) on Immunization as a multidisciplinary group of experts to provide high-level recommendations on vaccines and immunization.
This review provides an overview of SAGE's work in the past 25 years. It further outlines the processes and methods currently used by SAGE and highlights some of its major achievements.
SAGE's global policies have driven action toward eradication, elimination and disease control and addressed the optimization of vaccination and immunization. In total, 27 major policy positions on vaccines/vaccine-preventable diseases have guided global public health. During times of epidemics and pandemics, interim recommendations issued by SAGE have responded iteratively in real-time to provide evidence-driven response policies. SAGE is an adaptive advisory group that has modified its procedures and working approaches to meet the evolving challenges in public health and stay up-to-date with evolving scientific and guideline development standards.
Over the last quarter century, SAGE has significantly contributed to shaping the immunization landscape. It has achieved and maintained a high level of integrity and credibility. The advisory group continues to be an authority in global public health, and its recommendations have profound implications for the health of individuals and populations across the globe.
背景/目标：1999年11月，世界卫生组织设立了免疫战略咨询专家组（SAGE），作为一个多学科专家小组，就疫苗和免疫接种提供高级别建议。
本综述概述了SAGE在过去25年中的工作。它进一步概述了SAGE目前使用的流程和方法，并突出了其一些主要成就。
SAGE的全球政策推动了根除、消除和疾病控制行动，并涉及疫苗接种和免疫的优化。总共27项关于疫苗/疫苗可预防疾病的主要政策立场指导了全球公共卫生。在疫情和大流行期间，SAGE发布的临时建议实时反复做出回应，以提供循证应对政策。SAGE是一个适应性咨询小组，它修改了其程序和工作方法，以应对公共卫生领域不断演变的挑战，并跟上不断发展的科学和指南制定标准。
在过去的四分之一世纪里，SAGE为塑造免疫格局做出了重大贡献。它实现并保持了高度的诚信和信誉。该咨询小组仍然是全球公共卫生领域的权威机构，其建议对全球个人和人群的健康具有深远影响。
