Hoogenes N, Tomasoni M, Merkus P, Lissenberg-Witte B I, Leemans C R, Deganello A, Smit C F
Amsterdam UMC Location Vrije Universiteit Amsterdam, Otorhinolaryngology, De Boelelaan 1117, Amsterdam, the Netherlands.
University of Brescia, Otorhinolaryngology, Piazza Mercato 15, Brescia, Lombardia, Italy.
J Otol. 2024 Oct;19(4):227-233. doi: 10.1016/j.joto.2024.07.006. Epub 2024 Nov 5.
two new cases of temporal bone squamous cell carcinoma (TBSCC) with a bilateral occurrence are presented. Furthermore, a review of the literature was performed and the yearly incidence was calculated.
A systematic review of the literature was conducted using PRISMA guidelines.
Twenty-two more cases were found in literature. With a total of 24 cases, the calculated yearly incidence of bilateral TBSCC is 49:10^12 A history of chronic otitis or regional radiotherapy was found in respectively 50% and 12% of patients. In nine patients, the tumors developed synchronously (within 6 months) and in 13 metachronously.
The calculated incidence is 89 times higher than mathematically expected considering the incidence of unilateral cases. An explanation might be a history of chronic otitis or prior radiotherapy. The tumor staging of both the first tumor group and the contralateral tumor group are similar to unilateral temporal bone squamous cell carcinoma series.
报告2例双侧颞骨鳞状细胞癌（TBSCC）新病例。此外，对文献进行了回顾并计算了年发病率。
使用PRISMA指南对文献进行系统回顾。
文献中又发现22例病例。总共24例病例，计算出的双侧TBSCC年发病率为49:10^12。分别有50%和12%的患者有慢性中耳炎病史或局部放疗史。9例患者肿瘤同步发生（6个月内），13例为异时发生。
考虑到单侧病例的发病率，计算出的发病率比数学预期高89倍。一种解释可能是慢性中耳炎病史或既往放疗史。第一肿瘤组和对侧肿瘤组的肿瘤分期与单侧颞骨鳞状细胞癌系列相似。
