Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
BMC Microbiol. 2021 May 14;21(1):147. doi: 10.1186/s12866-021-02207-0.
Gestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM.
An analysis based on 16S rRNA microarray was performed on fecal samples obtained from 30 women with GDM and 28 healthy pregnant women.
We found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose.
This study suggests that there are large amounts of differentially abundant taxa between GDM and control group at the genus and the species level. Some of these taxa were correlated with blood glucose level and might be used as biomarkers for diagnoses and therapeutic targets for probiotics or synbiotics.
妊娠糖尿病（GDM）是一种常见的内分泌紊乱疾病，近年来其发病率呈上升趋势。近年来有报道称，GDM 与肠道微生物群的改变有关。然而，肠道微生物组在 GDM 病理生理学中的作用尚不清楚。本初步研究旨在对 GDM 患者的肠道微生物组进行物种水平解析，并评估其与 GDM 发生的关系。
对 30 名 GDM 妇女和 28 名健康孕妇的粪便样本进行基于 16S rRNA 微阵列的分析。
我们分别在属和种水平上发现了 54 个和 141 个 GDM 组和对照组之间差异丰度的分类群。在 GDM 患者中，厌氧消化链球菌与空腹血糖呈负相关，而某些物种（如嗜氧放线菌、考克氏菌）与空腹血糖呈正相关。
本研究表明，在属和种水平上，GDM 组和对照组之间存在大量差异丰度的分类群。其中一些分类群与血糖水平相关，可能作为诊断标志物，也可能作为益生菌或合生菌的治疗靶点。
