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研究加拿大娱乐用大麻合法化前后,患有严重并发精神健康和物质使用障碍的精神病患者中,大麻使用与情绪、焦虑及精神病症状之间的关系。

Examining the Relationship Between Cannabis Use and Mood, Anxiety, and Psychotic Symptoms in Psychiatric Patients with Severe Concurrent Mental Health and Substance Use Disorders Before and After Recreational Cannabis Legalization in Canada.

作者信息

Thiessen Karina A, Schütz Christian G

机构信息

Department of Psychiatry, Faculty of Medicine, University of British Columbia.

Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia.

出版信息

Cannabis. 2024 Dec 12;7(3):90-105. doi: 10.26828/cannabis/2024/000258. eCollection 2024.

Abstract

OBJECTIVE

The relationship between cannabis use and mental health has garnered significant attention in recent decades. However, studies have largely been in general populations or in countries in which recreational cannabis use is illegal.

METHOD

The current cross-sectional study examines the relationship between cannabis use, mood disorders, anxiety, and psychosis in an inpatient psychiatric population with severe concurrent mental health and substance use disorders, exploring the potential moderating effect of the legalization of recreational cannabis in Canada.

RESULTS

Cannabis use compared to non-use was associated with higher self-reported depression, anxiety, and psychotic symptoms but was not associated with diagnosis of a mood, anxiety, or psychotic disorder. Frequency of cannabis use was unrelated to mental health outcomes, but age of first use was negatively associated with self-reported psychoticism symptoms. There were some significant associations between recreational cannabis legalization and mental health, but legalization was largely unrelated to outcomes. There were also some significant differences by demographics.

CONCLUSIONS

While findings are relatively consistent with prior literature, some significant associations differed, suggesting the importance of examining concurrent disorder patients as a unique population when examining relationships between cannabis use and mental health.

摘要

目的

近几十年来,大麻使用与心理健康之间的关系备受关注。然而,相关研究主要针对普通人群或娱乐性大麻使用违法的国家。

方法

当前的横断面研究考察了患有严重并发心理健康和物质使用障碍的住院精神科患者中大麻使用、情绪障碍、焦虑和精神病之间的关系,探讨了加拿大娱乐性大麻合法化的潜在调节作用。

结果

与未使用大麻相比,使用大麻与更高的自我报告的抑郁、焦虑和精神病症状相关,但与情绪、焦虑或精神病性障碍的诊断无关。大麻使用频率与心理健康结果无关,但首次使用大麻的年龄与自我报告的精神病性症状呈负相关。娱乐性大麻合法化与心理健康之间存在一些显著关联,但合法化在很大程度上与结果无关。在人口统计学方面也存在一些显著差异。

结论

虽然研究结果与先前的文献相对一致,但一些显著关联有所不同,这表明在研究大麻使用与心理健康之间的关系时,将并发疾病患者作为一个独特群体进行考察具有重要意义。

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