Lu Jianguo, Zhao Xiangmei, Gan Shaoyin
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan, P. R. China.
School of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, P. R. China.
BMC Public Health. 2025 Jan 9;25(1):108. doi: 10.1186/s12889-024-21226-w.
The ambient particulate matter pollution may play a critical role in the initiation and development of tracheal, bronchus, and lung (TBL) cancer. Up to now, far too little attention has been paid to TBL cancer attributable to ambient particulate matter pollution. This study aims to assess the disease burden of TBL cancer attributable to ambient particulate matter pollution in global, regional and national from 1990 to 2021 to update the epidemiology data of this disease.
Leveraging data from the Global Burden of Disease (GBD) 2021 study, we analyzed the worldwide burden of TBL cancer resulting from ambient particulate matter pollution using indices including disability-adjusted life years (DALYs), age-standardised rate of DALYs (ASDR). This burden was further segmented based on variables including geographical location, and socio-demographic index (SDI), age and sex.
The ASDR per 100,000 population of TBL cancer attributable to ambient particulate matter pollution increased by 0.2%[95% UI 0.1 to 0.3] to 79.6[95% UI 49.0 to 111.2] from 1990 to 2021 Globally. Middle-aged and elderly individuals accounted for the majority of the disease burden, with the highest value at the 65-69 years. Most of the disease burden was concentrated in countries with High-middle SDI. There was a positive correlation between ASDR of TBL cancer due to particulate matter pollution and the SDI(ρ = 0.66, p < 0.001). East Asia and Central Europe exhibited higher observed values than the fitted curves, while such as Austraiasia South Asia and Western Sub-Saharan Africa had a lower observed values than the fitted curves. Decomposition analysis showed that population aging and growth were the two major drivers of the increase in DALYs.
The disease burden of TBL cancer attributable to ambient particulate matter pollution has increased, especially in regions and countries with High-middle SDI.
环境颗粒物污染可能在气管、支气管和肺癌（TBL癌）的发生和发展中起关键作用。到目前为止，人们对环境颗粒物污染导致的TBL癌关注太少。本研究旨在评估1990年至2021年全球、区域和国家层面环境颗粒物污染导致的TBL癌疾病负担，以更新该疾病的流行病学数据。
利用全球疾病负担（GBD）2021研究的数据，我们使用包括伤残调整生命年（DALYs）、年龄标准化DALYs率（ASDR）等指标，分析了环境颗粒物污染导致的全球TBL癌负担。该负担进一步按地理位置、社会人口指数（SDI）、年龄和性别等变量进行细分。
1990年至2021年全球范围内，每10万人中环境颗粒物污染导致的TBL癌ASDR增加了0.2%[95%UI 0.1至0.3]，达到79.6[95%UI 49.0至111.2]。中老年个体占疾病负担的大部分，65-69岁时负担最高。大部分疾病负担集中在高中等SDI的国家。颗粒物污染导致的TBL癌ASDR与SDI之间存在正相关（ρ = 0.66，p < 0.001）。东亚和中欧的观测值高于拟合曲线，而澳大拉西亚、南亚和撒哈拉以南非洲西部的观测值低于拟合曲线。分解分析表明，人口老龄化和增长是DALYs增加的两个主要驱动因素。
环境颗粒物污染导致的TBL癌疾病负担有所增加，尤其是在高中等SDI的地区和国家。
