从 Dryand. 中发现具有抗炎作用的三萜糖苷
Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Dryand.
机构信息
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China.
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemical & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
出版信息
Molecules. 2023 Feb 9;28(4):1658. doi: 10.3390/molecules28041658.
Two new triterpenoid glucosides, Heritiera A () and Heritiera B (), and six known triterpenoid analogs (-) were isolated from Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound substantially inhibits the release of nitric oxide (NO) with an IC value of 10.33 μM. The triterpenoids from could be used as potential candidates for the development of new anti-inflammatory agents.
从 中分离得到两个新的三萜糖苷，即 （）和 （），以及六个已知的三萜类似物（-）。通过综合光谱分析和与文献比较，确定了它们的结构。采用脂多糖（LPS）刺激 RAW 264.7 细胞模型评价了 的分离物的抗炎活性。结果表明，四种三萜具有很强的抗炎活性。在这些化合物中，化合物 对一氧化氮（NO）的释放有显著的抑制作用，IC 值为 10.33 μM。 中的三萜类化合物可以作为开发新型抗炎药物的潜在候选物。
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