晚期乳腺癌中的三重病毒感染：来自三例病例报告及文献综述的见解
Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review.
作者信息
Khasawneh Ashraf I, Himsawi Nisreen, Alorjani Mohammed, Al-Momani Hadeel, Shahin Uruk, Sammour Ashraf, Saleh Tareq, Al-Momani Hafez, Khasawneh Rame, Al Shboul Sofian
机构信息
Department of Microbiology, Pathology, and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
出版信息
Diagnostics (Basel). 2024 Dec 28;15(1):51. doi: 10.3390/diagnostics15010051.
Viral infections are typically considered contributing or secondary factors in the development of breast cancer. : This case report presents three instances of advanced breast cancer associated with triple viral infections. Case 1 involves a 78-year-old woman diagnosed with grade 2 invasive ductal carcinoma positive for HPV-18, CMV, and BLV. Case 2 describes a 39-year-old woman with grade 2 invasive ductal carcinoma, positive for HPV-16, CMV, and BLV. Case 3 is a 52-year-old woman with grade 3 invasive ductal carcinoma, positive for HPV-16, BLV, and MMTV. These cases suggest a possible correlation between viral co-infections and breast cancer aggressiveness, posing new questions about the role of viral infections in cancer development and prognosis. The findings contribute to growing evidence that viral infections may influence the progression and therapeutic response of breast cancer, warranting further investigation into targeted preventive measures including vaccinations.
病毒感染通常被认为是乳腺癌发生的促成因素或次要因素。本病例报告展示了三例与三重病毒感染相关的晚期乳腺癌病例。病例1为一名78岁女性，被诊断为2级浸润性导管癌，HPV - 18、巨细胞病毒（CMV）和牛白血病病毒（BLV）检测呈阳性。病例2描述了一名39岁女性，患有2级浸润性导管癌，HPV - 16、CMV和BLV检测呈阳性。病例3是一名52岁女性，患有3级浸润性导管癌，HPV - 16、BLV和小鼠乳腺肿瘤病毒（MMTV）检测呈阳性。这些病例表明病毒合并感染与乳腺癌侵袭性之间可能存在关联，这对病毒感染在癌症发生和预后中的作用提出了新问题。这些发现进一步证明了病毒感染可能影响乳腺癌的进展和治疗反应，有必要进一步研究包括疫苗接种在内的针对性预防措施。
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