在卡塔尔乳腺癌中 HPV、EBV 和 MMTV 样病毒的感染率。
Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar.
机构信息
College of Medicine, QU Health, Qatar University, Doha, Qatar.
Department of Pathology, Hamad General Hospital, Doha, Qatar.
出版信息
Intervirology. 2022;65(4):188-194. doi: 10.1159/000525277. Epub 2022 May 31.
INTRODUCTION
Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear.
METHODS
We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR.
RESULTS
We found the presence of HPV and EBV in 65% and 49% of our cancer sample cohorts; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; no significant association was noted between the co-presence of these viruses and the clinicopathological features.
CONCLUSION
Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.
简介
人乳头瘤病毒（HPV）、EB 病毒（EBV）和鼠乳腺肿瘤病毒样病毒（MMTV 样病毒）可存在并促进乳腺癌的发生和发展。然而，这些致癌病毒及其相互作用在乳腺癌中的作用仍不清楚。
方法
我们使用 PCR 技术在 74 份来自卡塔尔的乳腺癌样本中探索了高危型 HPV、EBV 和 MMTV 样病毒的共同存在情况。
结果
我们发现，HPV 和 EBV 在我们的癌症样本队列中分别存在于 65%和 49%的样本中；47%的样本同时存在这两种致癌病毒。单独的 MMTV 样病毒在 15%的样本中被检测到，但与临床病理特征无显著相关性。这三种致癌病毒在 14%的病例中同时存在，但它们的共同存在与临床病理特征之间没有显著关联。
结论
尽管存在致癌病毒，但还需要进一步研究以了解它们在人类乳腺癌发生中的相互作用。
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