Argento Giacomo, Rendina Erino Angelo, Maurizi Giulio
Department of Thoracic Surgery, University of Rome La Sapienza, Sant'Andrea Hospital, 00189 Rome, Italy.
Cancers (Basel). 2025 Jan 2;17(1):115. doi: 10.3390/cancers17010115.
The landscape of surgical oncology is rapidly evolving with the advent of precision medicine, driven by breakthroughs in genomics and proteomics. This article explores how integrating molecular data is transforming surgical decision-making and enabling personalized treatment strategies. We examine emerging technologies such as next-generation sequencing, proteomic analysis, and molecular imaging, which provide critical insights into tumor biology and guide surgical interventions. The article also highlights the application of genomic and proteomic data in preoperative planning and the development of personalized resection strategies. Additionally, we will address the current challenges and future opportunities in this rapidly evolving field, emphasizing the need for continuous education, interdisciplinary collaboration, and ongoing research to fully realize the potential of precision medicine in thoracic surgical oncology, paving the way for more effective and individualized cancer treatments.
随着精准医学的出现，外科肿瘤学领域正在迅速发展，这一发展由基因组学和蛋白质组学的突破所推动。本文探讨了整合分子数据如何改变手术决策并促成个性化治疗策略。我们研究了诸如新一代测序、蛋白质组分析和分子成像等新兴技术，这些技术为肿瘤生物学提供了关键见解并指导手术干预。本文还强调了基因组和蛋白质组数据在术前规划及个性化切除策略制定中的应用。此外，我们将探讨这一快速发展领域当前面临的挑战和未来机遇，强调持续教育、跨学科合作以及持续研究的必要性，以充分实现精准医学在胸外科肿瘤学中的潜力，为更有效和个性化的癌症治疗铺平道路。
