Cingulate and striatal hubs are linked to early skill learning.

Early skill learning develops in the context of activity changes in distributed cortico-subcortical regions. Here, we investigated network hubs-centers of information integration and transmission-within the brain network supporting early skill learning. We recorded magnetoencephalographic (MEG) brain activity in healthy human subjects who learned a moderately difficult sequence skill with their non-dominant left hand. We then computed network hub strength by summing top 10% functional connectivity over 86 parcellated brain regions (AAL3 atlas) and five brain oscillatory frequency bands (alpha, low-, high-beta, low- and high-gamma). Virtually all skill gains developed during rest intervals of early learning (micro-offline gains). MEG hub strength in the alpha band (8-13Hz) in bilateral anterior cingulate (ACC) and caudate and in the low-beta band (13-16Hz) in bilateral caudate and right putamen correlated with micro-offline gains. These regions linked strongly with the hippocampus, parahippocampal cortex, and lingual and fusiform gyri. Thus, alpha and low-beta brain oscillatory activity in cingulate and striatal regions appear to contribute as hubs of information integration and transmission during early skill learning.