Miranda Bruno Pires, da Silva Amanda Figueira, Ascenção Júlia de Castro, Santos Helena Lúcia Carneiro
Dentistry in Oral Biology and Pathology, PhD in Progress in Tropical Medicine, Oswaldo Cruz Institute, Brazil.
Tropical Medicine, PhD in Progress in Tropical Medicine, Oswaldo Cruz Institute, Brazil.
Arch Oral Biol. 2025 Apr;172:106121. doi: 10.1016/j.archoralbio.2024.106121. Epub 2024 Nov 10.
To provide a comprehensive summary of the available evidence on the oral microbiota of humans and non-human primates about the etiology of periodontal disease.
An integrative literature review was conducted on 398 clinical and observational articles published between 2010 and 2024 using searches in the MEDLINE/PubMed, Virtual Health Library, and SciELO databases. After the screening, eligibility, data extraction, and methodological quality assessment, 21 studies were selected.
The results, which reveal striking similarities between the pathogens involved in periodontal disease in humans and NHPs, confirm the potential of NHPs as research models and inspire further research in this area.
According to these studies, Actinomyces spp., Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Capnocytophaga spp., Eubacterium spp., Filifactor alocis, Fusobacterium spp., Leptotrichia spp., Neisseria mucosa, Parvimonas micra, Porphyromonas spp., Prevotella spp., Selenomonas spp., Streptococcus spp., Treponema spp., Tannerella spp., Veillonella parvula, were the genus and/or species of bacteria found in humans. On the other hand, Aggregatibacter acinomycetemcomitans, Campylobacter rectus, Desulfobulbus spp., Dialister invisus, Eikenella corrodens, Filifactor alocis, Fusobacterium spp., Parvimonas micra, Porphyromonas spp., Prevotella spp., Staphylococcus spp., Streptococcus spp., Treponema spp., Tannerella spp., Veillonella spp., were the most reported in NHPs. No study in non-human primates reported the presence of protozoa, unlike studies in humans that reported the presence of Entamoeba gingivalis and Trichomonas tenax. However, its role in periodontal disease still needs to be elucidated, despite the strong association mainly with severe periodontal disease where protozoa are observed in injured tissues.
全面总结关于人类和非人灵长类动物口腔微生物群与牙周病病因的现有证据。
对2010年至2024年间发表在MEDLINE/PubMed、虚拟健康图书馆和SciELO数据库中的398篇临床和观察性文章进行综合文献综述。经过筛选、合格性评估、数据提取和方法学质量评估后，选取了21项研究。
结果显示人类和非人灵长类动物牙周病相关病原体之间存在显著相似性，证实了非人灵长类动物作为研究模型的潜力，并激发了该领域的进一步研究。
根据这些研究，放线菌属、伴放线聚集杆菌、直肠弯曲菌、二氧化碳嗜纤维菌属、真杆菌属、具核梭杆菌、梭杆菌属、纤毛菌属、黏液奈瑟菌、微小单胞菌、卟啉单胞菌属、普氏菌属、栖瘤胃普雷沃菌属、链球菌属、密螺旋体属、坦纳菌属、小韦荣球菌是在人类中发现的细菌属和/或种。另一方面，伴放线聚集杆菌、直肠弯曲菌、脱硫球菌属、不可见戴阿利斯特菌、腐蚀艾肯菌、具核梭杆菌、梭杆菌属、微小单胞菌、卟啉单胞菌属、普氏菌属、葡萄球菌属、链球菌属、密螺旋体属、坦纳菌属、韦荣球菌属是在非人灵长类动物中报道最多的。与人类研究报告牙龈内阿米巴和口腔毛滴虫的存在不同，没有关于非人灵长类动物原生动物存在的研究。然而，尽管主要与在受损组织中观察到原生动物的严重牙周病有很强的关联，但其在牙周病中的作用仍有待阐明。
