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肥胖对不同牙周状况受试者龈下微生物群组成的影响：一项系统评价

Influence of obesity on subgingival microbiota composition in subjects with different periodontal status: a systematic review.

作者信息

Alarcón-Sánchez Mario Alberto

机构信息

Department of Research in Microbiology, Faculty of Chemical and Biological Sciences, Autonomous University of Guerrero, Chilpancingo 39090. Guerrero, Mexico.

出版信息

Rev Cient Odontol (Lima). 2024 Mar 30;12(1):e187. doi: 10.21142/2523-2754-1201-2024-187. eCollection 2024 Jan-Mar.

DOI:10.21142/2523-2754-1201-2024-187
PMID:39015311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11247467/
Abstract

OBJECTIVE

This systematic review aimed to investigate the changes in the composition of the subgingival microbiota among subjects with normo-weight, overweight and obesity, in conditions of periodontal health and disease.

MATERIALS AND METHODS

The protocol for this study was designed following PRISMA guidelines. Records were identified using different search engines (PubMed/MedLine, Scopus and Web of Science). Observational studies, in human subjects diagnosed with obesity (BMI >30kg/m) and periodontal disease (gingivitis and periodontitis), on the analysis of subgingival microbiota were selected. Eight articles were included.

RESULTS

The subgingival microbiota of 1,229 subjects (n=894 exposure group and n=335 control group) was analyzed. Periodontal pathogens were the most common bacteria detected in subjects with obesity and periodontitis (, , , , . , , , , and ), as along with some accessory pathogens such as: , and that favor the virulence of late colonizers.

CONCLUSIONS

Although there are evident alterations in the composition of the subgingival microbiota in subjects with obesity and periodontitis, it is still a challenge to identify a specific pattern of microbiota in these subjects. If associations between subgingival plaque microorganisms and obesity are confirmed, microbiome analysis could be a useful tool to improve preventive measures and the management of people with obesity.

摘要

目的

本系统评价旨在调查体重正常、超重和肥胖受试者在牙周健康和疾病状况下龈下微生物群组成的变化。

材料与方法

本研究方案依据PRISMA指南设计。使用不同的搜索引擎（PubMed/MedLine、Scopus和Web of Science）检索记录。选择对诊断为肥胖（BMI>30kg/m）和牙周疾病（牙龈炎和牙周炎）的人类受试者龈下微生物群进行分析的观察性研究。共纳入8篇文章。

结果

分析了1229名受试者（n=894暴露组和n=335对照组）的龈下微生物群。牙周病原体是在肥胖和牙周炎受试者中检测到的最常见细菌（， ， ， ， ， ， ， ， ， ），以及一些辅助病原体，如： 、 和 ，这些病原体有利于晚期定植菌的毒力。

结论

尽管肥胖和牙周炎受试者的龈下微生物群组成有明显改变，但在这些受试者中识别特定的微生物群模式仍是一项挑战。如果龈下菌斑微生物与肥胖之间的关联得到证实，微生物组分析可能是改善肥胖人群预防措施和管理的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb4/11247467/a7323dce619b/odontologica-12-01-e187-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb4/11247467/16d402ceaf22/odontologica-12-01-e187-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb4/11247467/a7323dce619b/odontologica-12-01-e187-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb4/11247467/16d402ceaf22/odontologica-12-01-e187-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb4/11247467/a7323dce619b/odontologica-12-01-e187-gf2.jpg

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Nutrients. 2023 Jun 17;15(12):2787. doi: 10.3390/nu15122787.
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Effect of being overweight and obese on periodontal treatment costs.超重和肥胖对牙周治疗费用的影响。
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Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis.
牙周炎发病机制的当前概念：从共生到生态失调。
J Oral Microbiol. 2023 Apr 2;15(1):2197779. doi: 10.1080/20002297.2023.2197779. eCollection 2023.
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Dysbiosis of the Subgingival Microbiome and Relation to Periodontal Disease in Association with Obesity and Overweight.龈下微生物组失调与牙周病的关系及其与肥胖和超重的关联。
Nutrients. 2023 Feb 6;15(4):826. doi: 10.3390/nu15040826.
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Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review.种植体生物材料对牙周组织的潜在影响：全面综述。
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Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta-analysis of epidemiological studies.2011 年至 2020 年间有牙人群牙周炎的流行率：系统评价和流行病学研究的荟萃分析。
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Obesity and periodontitis: A systematic review and updated meta-analysis.肥胖与牙周炎：系统评价与更新的荟萃分析。
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