Yamagishi H, Kunisada T, Takeda T
Mech Ageing Dev. 1985 Jan;29(1):101-3. doi: 10.1016/0047-6374(85)90051-x.
Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of 0.4-0.8 microns in contour length was amplified several-fold at 26 months of age. In senescence-prone series (SAM-P), a similar amplification of small circular DNAs was observed at young age of 10 weeks and more progressive at 17 months of age.
采用云母压片吸附法检测了快速衰老近交系小鼠外周血淋巴细胞中的染色体外环状DNA复合物。在抗衰老品系（SAM-R）中，7周龄时观察到多分散的环状DNA，在26月龄时，轮廓长度为0.4 - 0.8微米的小环状形式的特定大小类别扩增了几倍。在易衰老品系（SAM-P）中，10周龄幼鼠时观察到小环状DNA有类似的扩增，在17月龄时更为明显。
