Castaño-Jaramillo Lina M, Rodríguez Olga, Vélez-Tirado Natalia
Servicio de Inmunología Clínica y Alergia Pediátrica, HOMI Fundación Hospital Pediátrico de La Misericordia, Bogotá, D. C., Colombia.
Servicio de Pediatría, HOMI Fundación Hospital Pediátrico de La Misericordia, Bogotá, D. C., Colombia.
Biomedica. 2024 Dec 23;44(Sp. 2):51-62. doi: 10.7705/biomedica.7398.
Predominant antibody deficiency is the most frequent group of innate immunity errors, but information about patients’ nutritional status is scarce.
To characterize the nutritional status of Colombian patients with predominant antibody deficiencies.
Material and methods. We analyzed medical charts of patients with predominant antibody deficiency in a pediatric hospital in Bogotá.
We analyzed 55 medical charts. The most frequent diagnoses were specific deficiencies of polysaccharide antibodies and immunoglobulin A, common variable immunodeficiency, and agammaglobulinemia. More than 70% of the patients had sinopulmonary infections, with pneumonia being the most frequent, followed by otitis and sinusitis. In children under five years, 45% had adequate weight for their height, 18% had a risk of malnutrition, and 18% had moderate acute malnutrition. Four-point-five percent had obesity, 4.5% showed overweight, and 9% had a risk of being overweight. Of those older than five years, 54% had an adequate body mass index, 22.5% showed overweight, 9.6% were at risk of thinness, and 9.6% were thin. We found that the risk of short stature and short stature per se were more frequent than the expected height in these patients. The percentages of patients with short stature were higher than those reported nationally.
Due to the epidemic of childhood obesity, it will be more frequent to find overweight or obesity in children above five years. Therefore, finding short stature could be a more sensitive alarm sign for predominant antibody deficiency.
主要抗体缺陷是先天性免疫错误中最常见的一组，但关于患者营养状况的信息却很少。
描述哥伦比亚主要抗体缺陷患者的营养状况。
我们分析了波哥大一家儿科医院主要抗体缺陷患者的病历。
我们分析了55份病历。最常见的诊断是多糖抗体和免疫球蛋白A的特异性缺陷、常见变异型免疫缺陷和无丙种球蛋白血症。超过70%的患者患有鼻窦肺部感染，其中肺炎最为常见，其次是中耳炎和鼻窦炎。在5岁以下儿童中，45%的儿童身高体重正常，18%有营养不良风险，18%患有中度急性营养不良。4.5%的儿童肥胖，4.5%超重，9%有超重风险。在5岁以上的儿童中，54%的儿童体重指数正常，22.5%超重，9.6%有消瘦风险，9.6%消瘦。我们发现，这些患者中身材矮小的风险和身材矮小本身比预期身高更为常见。身材矮小患者的百分比高于全国报告的水平。
由于儿童肥胖的流行，5岁以上儿童超重或肥胖的情况将更为常见。因此，发现身材矮小可能是主要抗体缺陷更敏感的警示信号。
