Tian Wenqiang, Wang Xu, Zhang Yan, Weng Ting, Chaker Tlili, Chen Xiaohan, Kong Qingke, Wang Deqiang
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China.
Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, China.
Biosensors (Basel). 2025 Jan 13;15(1):41. doi: 10.3390/bios15010041.
In recent years, environmental and food safety have garnered substantial focus due to their intimate connection with human health. Numerous biosensors have been developed for identifying deleterious compounds; however, these biosensors reveal certain limitations. Nanopore sensors, featuring nano-scaled pore size, have demonstrated outstanding performance in terms of rapidity, sensitivity, and selectivity as a single-molecule technique for environmental and food surveillance. In this review, we present a comprehensive overview of nanopore applications in these two fields. To elucidate the pioneering roles of nanopores, analytes are categorized into three distinct groups, including metal ions, synthetic contaminants, and biotoxins. Moreover, a variety of strategies are involved, such as the coalescence with ligand probes, the implementation of chemical reactions, the functionalization of nanopores, etc. These scientific studies showcase the versatility and diversity of the nanopore technique, paving the way for further developments of nanopore technology in environmental and food safety.
近年来，环境与食品安全因其与人类健康的密切关联而备受关注。人们已开发出众多用于识别有害化合物的生物传感器；然而，这些生物传感器存在一定局限性。纳米孔传感器具有纳米级孔径，作为一种用于环境与食品监测的单分子技术，在速度、灵敏度和选择性方面展现出卓越性能。在本综述中，我们全面概述了纳米孔在这两个领域的应用。为阐明纳米孔的开创性作用，将分析物分为三类，包括金属离子、合成污染物和生物毒素。此外，还涉及多种策略，如与配体探针结合、进行化学反应、对纳米孔进行功能化等。这些科学研究展示了纳米孔技术的多功能性和多样性，为纳米孔技术在环境与食品安全领域的进一步发展铺平了道路。
