Pachal Shantanu, Kumar Hitesh, Jain Rupshee, Goel Bhawna, Kesharwani Sharyu, Kesharwani Siddharth S, Jain Vikas
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, India.
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, India.
Mol Biol Rep. 2025 Jan 24;52(1):159. doi: 10.1007/s11033-025-10261-4.
Phytochemicals are bioactive secondary plant metabolites found in high concentrations in fruits, grains, and vegetables. Recent studies provide evidence of usage of plant-based diets rich in phytochemicals and their corelation to reduction in cancer incidence. Several phytochemicals have demonstrated effectiveness as chemotherapeutic agents against various cancers, including breast cancer. Breast cancer (BC) is a major worldwide medical issue owing to its high incidence, especially in women. It is the most often detected malignancy and an important trigger of mortality in women. Various chemotherapeutics along with radiotherapy are being investigated as potential treatment options for breast cancer. However, multidrug resistance, toxicity to normal cells, and other adverse effects limit the usage of chemotherapeutics in breast cancer. Cancer treatment with dietary phytochemicals is a highly effective approach that is currently gaining widespread attention. This manuscript intends to describe the existing data on the anticancer effects of various phytochemicals, including their preclinical exploration against breast cancer. Phytochemicals are broadly categorized, with an explanation of their role in breast cancer prognosis through various signalling pathways, preclinical status, physicochemical property analysis using Data Warrior, and evidence on individual phototherapeutics.
植物化学物质是在水果、谷物和蔬菜中大量存在的具有生物活性的次生植物代谢产物。最近的研究为富含植物化学物质的植物性饮食的使用及其与癌症发病率降低的相关性提供了证据。几种植物化学物质已被证明作为抗多种癌症（包括乳腺癌）的化疗药物具有有效性。乳腺癌（BC）因其高发病率，尤其是在女性中的高发病率，成为全球主要的医学问题。它是女性中最常检测到的恶性肿瘤，也是导致女性死亡的重要诱因。各种化疗药物以及放射疗法正在作为乳腺癌的潜在治疗选择进行研究。然而，多药耐药性、对正常细胞的毒性以及其他不良反应限制了化疗药物在乳腺癌治疗中的应用。用膳食植物化学物质进行癌症治疗是一种目前正受到广泛关注的高效方法。本手稿旨在描述各种植物化学物质抗癌作用的现有数据，包括它们对乳腺癌的临床前研究。植物化学物质被广泛分类，并解释了它们通过各种信号通路在乳腺癌预后中的作用、临床前状况、使用Data Warrior进行的物理化学性质分析以及个别光疗药物的证据。
