Lee Yeo Jin, Jee Donghyun
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Ophthalmology and Visual Science, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
PLoS One. 2025 Jan 24;20(1):e0316438. doi: 10.1371/journal.pone.0316438. eCollection 2025.
We sought to evaluate the relationship between blood vitamin A levels and myopia in adults aged ≥20 years in Korea.
We collected data of 15,899 participants aged ≥20 years from the Korean National Health and Nutrition Examination Survey. Participants underwent refraction tests to identify myopia and high myopia, and their blood pressure and obesity levels were measured. Blood tests were conducted to assess vitamin A, fasting blood glucose, triglyceride, and total cholesterol levels. Blood vitamin A levels were classified into quartiles.
After adjusting for confounding variables like age, sex, income, education, hypertension, diabetes, and obesity, the odds ratio (OR) of blood vitamin A in the second quartile for myopia was 0.66, while the OR in the fourth quartile was 0.74 (P for trend < 0.001). Among women, the ORs for myopia in the second and third quartiles of blood vitamin A levels were 0.48 (95% confidence interval [CI], 0.35-0.66) and 0.67 (95% CI, 0.49-0.90), respectively (P for trend < 0.001). In men, the ORs for high myopia in the second, third, and fourth quartiles of blood vitamin A levels were 0.05 (95% CI, 0.004-0.58), 0.15 (95% CI, 0.024-0.91), and 0.05 (95% CI, 0.008-0.364), respectively (P for trend < 0.001).
An inverse relationship was observed between higher blood vitamin A levels and the prevalence of myopia. Notably, higher blood vitamin A levels were associated with a lower prevalence of high myopia in men and a lower prevalence of myopia in women.
我们旨在评估韩国20岁及以上成年人血液中维生素A水平与近视之间的关系。
我们从韩国国民健康与营养检查调查中收集了15899名20岁及以上参与者的数据。参与者接受了屈光测试以确定近视和高度近视，并测量了他们的血压和肥胖水平。进行血液检测以评估维生素A、空腹血糖、甘油三酯和总胆固醇水平。血液维生素A水平被分为四分位数。
在调整了年龄、性别、收入、教育程度、高血压、糖尿病和肥胖等混杂变量后，血液维生素A处于第二四分位数时近视的优势比（OR）为0.66，而处于第四四分位数时的OR为0.74（趋势P<0.001）。在女性中，血液维生素A水平处于第二和第三四分位数时近视的OR分别为0.48（95%置信区间[CI]，0.35 - 0.66）和0.67（95%CI，0.49 - 0.90）（趋势P<0.001）。在男性中，血液维生素A水平处于第二、第三和第四四分位数时高度近视的OR分别为0.05（95%CI，0.004 - 0.58）、0.15（95%CI，0.024 - 0.91）和0.05（95%CI，0.008 - 0.364）（趋势P<0.001）。
观察到血液中较高的维生素A水平与近视患病率之间存在负相关关系。值得注意的是，较高的血液维生素A水平与男性高度近视患病率较低以及女性近视患病率较低相关。
