A Comparative Review: Biological Safety and Sustainability of Metal Nanomaterials Without and with Machine Learning Assistance.

In recent years, metal nanomaterials and nanoproducts have been developed intensively, and they are now widely applied across various sectors, including energy, aerospace, agriculture, industry, and biomedicine. However, nanomaterials have been identified as potentially toxic, with the toxicity of metal nanoparticles posing significant risks to both human health and the environment. Therefore, the toxicological risk assessment of metal nanomaterials is essential to identify and mitigate potential adverse effects. This review provides a comprehensive analysis of the safety and sustainability of metallic nanoparticles (such as Au NPs, Ag NPs, etc.) in key domains such as medicine, energy, and environmental protection. Using a dual-perspective analysis approach, it highlights the unique advantages of machine learning in data processing, predictive modeling, and optimization. At the same time, it underscores the importance of traditional methods, particularly their ability to offer greater interpretability and more intuitive results in specific contexts. Finally, a comparative analysis of traditional methods and machine learning techniques for detecting the toxicity of metal nanomaterials is presented, emphasizing the key challenges that need to be addressed in future research.