Lopez April D, Whyms Sophie, Luker Hailey A, Galvan Claudia J, Holguin F Omar, Hansen Immo A
Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA.
NatPro Centre, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, 2 Dublin, Ireland.
Insects. 2025 Jan 7;16(1):51. doi: 10.3390/insects16010051.
Plant-based oils have a long history of use as insect repellents. In an earlier study, we showed that in a 10% concentration, geraniol, 2-phenylethl propionate, and the plant-based essential oils clove and cinnamon effectively protected from mosquito bites for over 60 min. To expand on this study, we reanalyzed our GC-MS data to identify the short organic constituents of these oils. We then used an arm-in-cage assay to test the repellency of different concentrations and combinations of these oils and pure compounds. We found a sigmoidal relationship between the complete protection time from mosquito bites and the concentration of these oils. The complete protection times we recorded for combinations of these oils suggest an absence of additive effects. The results of this study can inform the development of novel, effective, and plant-based insect repellents.
植物油作为驱虫剂已有悠久的使用历史。在早期的一项研究中，我们发现，浓度为10%时，香叶醇、2-苯乙基丙酸酯以及植物精油丁香和肉桂能有效防止蚊虫叮咬长达60多分钟。为了拓展这项研究，我们重新分析了气相色谱-质谱联用（GC-MS）数据，以确定这些油中的短链有机成分。然后，我们采用笼内手臂试验来测试这些油及纯化合物不同浓度和组合的驱蚊效果。我们发现，蚊虫叮咬的完全防护时间与这些油的浓度之间呈S形关系。我们记录的这些油组合的完全防护时间表明不存在相加效应。本研究结果可为新型、有效且基于植物的驱虫剂的开发提供参考。
