铜催化的交叉脱氢偶联反应：一种通过sp(3) C-H键的氧化活化形成碳-碳键的通用策略。
Cu-catalyzed cross-dehydrogenative coupling: a versatile strategy for C-C bond formations via the oxidative activation of sp(3) C-H bonds.
作者信息
Li Zhiping, Bohle D Scott, Li Chao-Jun
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 2K6.
出版信息
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8928-33. doi: 10.1073/pnas.0601687103. Epub 2006 Jun 5.
Abstract
Cu-catalyzed cross-dehydrogenative coupling (CDC) methodologies were developed based on the oxidative activation of sp(3) C-H bonds adjacent to a nitrogen atom. Various sp, sp(2), and sp(3) C-H bonds of pronucleophiles were used in the Cu-catalyzed CDC reactions. Based on these results, the mechanisms of the CDC reactions also are discussed.
摘要
基于与氮原子相邻的sp(3) C-H键的氧化活化，开发了铜催化的交叉脱氢偶联（CDC）方法。亲核前驱体的各种sp、sp(2)和sp(3) C-H键被用于铜催化的CDC反应。基于这些结果，还讨论了CDC反应的机理。
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