Park Hye-In, Sung A-Young
Department of Optometry & Vision Science, Daegu Catholic University, Gyeongsan 38430, Republic of Korea.
Polymers (Basel). 2025 Jan 10;17(2):159. doi: 10.3390/polym17020159.
This study aims to build an optimal drug delivery system by manufacturing and evaluating a hydrogel contact lens using Tretinoin (ATRA) and protein nanoparticles to improve the drug delivery system as an ophthalmic medical contact lens. To evaluate the optical and physical properties of the manufactured lens, the spectral transmittance, refractive index, water content, contact angle, AFM, tensile strength, drug delivery, and antibacterial properties were analyzed. The contact lens was manufactured to contain ATRA and bovine serum albumin (BSA) in different ways, and the results confirmed that A, B, and C each had different physical properties. In particular, for Sample A, using the soak and release method and using ATRA solution in the contact lens with BSA added, the wettability was 55.94°, the tensile strength was 0.1491 kgf/mm, and drug delivery released 130.35 μm over 336 h, which was found to be superior to samples B and C. Therefore, the three hydrogel contact lenses compared in this study according to the addition method of ATRA and BSA can be used in various ways to build an optimal drug delivery system that is very useful as an ophthalmic medical lens.
本研究旨在通过制备和评估一种使用维甲酸（全反式维甲酸，ATRA）和蛋白质纳米颗粒的水凝胶隐形眼镜来构建一种优化的药物递送系统，以改进作为眼科医用隐形眼镜的药物递送系统。为了评估所制备镜片的光学和物理性质，对光谱透过率、折射率、含水量、接触角、原子力显微镜、拉伸强度、药物递送和抗菌性能进行了分析。以不同方式制备了含有ATRA和牛血清白蛋白（BSA）的隐形眼镜，结果证实A、B和C各自具有不同的物理性质。特别是对于样品A，采用浸泡和释放方法，并在添加了BSA的隐形眼镜中使用ATRA溶液，其润湿性为55.94°，拉伸强度为0.1491 kgf/mm，在336小时内药物递送释放量为130.35μm，发现优于样品B和C。因此，本研究中根据ATRA和BSA添加方法比较的三种水凝胶隐形眼镜可以以各种方式用于构建一种优化的药物递送系统，该系统作为眼科医用镜片非常有用。
