Hariharan S, Karnan Hemalatha, Maheswari D Uma
School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
School of Computing, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
Sci Rep. 2025 Jan 25;15(1):3212. doi: 10.1038/s41598-025-87946-0.
Mechanical ventilation is the process through which breathing support is provided to patients who face inconvenience during respiration. During the pandemic, many people were suffering from lung disorders, which elevated the demand for mechanical ventilators. The handling of mechanical ventilators is to be done under the assistance of trained professionals and demands the selection of ideal parameters. In this work, a computer-aided simulation of ventilator design is performed for clinical complications like pneumonia and Chronic Obstructive Pulmonary Disease (COPD) and is validated against normal ventilatory parameters. The parameters such as tidal volume, respiratory rate, and inspiration to expiration ratio (I: E) are considered as control values to check the stability of the mechanical ventilator for stern performance. The check valves 1 and 2 governed by the control parameters provide optimal volume that must be sent inside the tracheal region. The hyperparameters are tuned using a low intricate feed-forward neural network (FFNN). The trained features serve as input to the sensors present in the mimicked lung model. The performance metrics of FFNN during the training and testing phases substantiate the optimal performance of the ventilator. The simulation and validation results indicate that the designed ventilator system is stable and effective for clinical use, providing optimal respiratory support for patients with pneumonia and COPD.
机械通气是为呼吸过程中面临不便的患者提供呼吸支持的过程。在疫情期间,许多人患有肺部疾病,这增加了对机械通气机的需求。机械通气机的操作需在训练有素的专业人员协助下进行,并且需要选择理想的参数。在这项工作中,针对肺炎和慢性阻塞性肺疾病(COPD)等临床并发症进行了通气机设计的计算机辅助模拟,并根据正常通气参数进行了验证。诸如潮气量、呼吸频率和吸气与呼气比(I:E)等参数被视为控制值,以检查机械通气机在严格性能下的稳定性。由控制参数控制的止回阀1和2提供必须输送到气管区域内的最佳气量。使用低复杂度前馈神经网络(FFNN)对超参数进行调整。经过训练的特征作为模拟肺模型中存在的传感器的输入。FFNN在训练和测试阶段的性能指标证实了通气机的最佳性能。模拟和验证结果表明,所设计的通气机系统在临床使用中稳定且有效,可为肺炎和COPD患者提供最佳呼吸支持。