Fatemi Nayeralsadat, Mirbahari Seyedeh Nasim, Tierling Sascha, Sanjabi Fatemeh, Shahrivari Shabnam, AmeliMojarad Mandana, Amelimojarad Melika, Mirzaei Rezaei Meygol, Nobaveh Parsa, Totonchi Mehdi, Nazemalhosseini Mojarad Ehsan
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran.
Dig Dis Sci. 2025 Mar;70(3):919-942. doi: 10.1007/s10620-024-08774-2. Epub 2025 Jan 27.
Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related deaths globally, necessitating urgent advancements in therapeutic approaches. The emergence of groundbreaking therapies, including chimeric antigen receptor-T (CAR-T) cell therapies, oncolytic viruses, and immune checkpoint inhibitors, marks a transformative era in oncology. These innovative modalities, tailored to individual genetic and molecular profiles, hold the promise of significantly enhancing patient outcomes. This comprehensive review explores the latest clinical trials and advancements, encompassing targeted molecular therapies, immunomodulatory agents, and cell-based therapies. By evaluating the strengths, limitations, and potential synergies of these approaches, this research aims to reshape the treatment landscape and improve clinical outcomes for CRC patients, offering new found hope for those who have exhausted conventional options. The culmination of this work is anticipated to pave the way for transformative clinical trials, ushering in a new era of personalized and effective CRC therapy.
结直肠癌（CRC）是全球癌症相关死亡的第二大主要原因，因此迫切需要在治疗方法上取得进展。包括嵌合抗原受体T（CAR-T）细胞疗法、溶瘤病毒和免疫检查点抑制剂在内的突破性疗法的出现，标志着肿瘤学进入了一个变革性的时代。这些针对个体基因和分子特征量身定制的创新疗法，有望显著改善患者的治疗效果。这篇全面的综述探讨了最新的临床试验和进展，包括靶向分子疗法、免疫调节剂和基于细胞的疗法。通过评估这些方法的优势、局限性和潜在协同作用，本研究旨在重塑治疗格局，改善CRC患者的临床结局，为那些已用尽传统治疗方案的患者带来新的希望。预计这项工作的成果将为变革性临床试验铺平道路，迎来个性化且有效的CRC治疗新时代。
